Tbio B3GNT2 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

Protein Summary

Description

Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors (PubMed:9892646). Probably constitutes the main polylactosamine synthase. This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q9NY97
• Q54AC1
• Q9NQQ9
• Q9NQR0
• Q9NUT9

Gene Name

• B3GNT2

Ensembl ID

• ENST00000301998
• ENSP00000305595
• ENSG00000170340
• ENST00000405767
• ENSP00000384692

Symbol

• B3GALT7
• B3GNT1
• B3GNT
• BGNT2
• B3GNT1
• BGnT-2
• beta-1
• 3-Gn-T1
• 3-Gn-T2
• B3GN-T2
• B3GNT-2
• BETA3GNT
• beta3Gn-T1
• beta3Gn-T2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
transcription factor binding site profile	0.88
pathway	0.84
tissue sample	0.74
transcription factor	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / N-acetyllactosaminide Beta-1,3-n-acetylglucosaminyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / N-acetyllactosaminide Beta-1,3-n-acetylglucosaminyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.11   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.11   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0