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Tbio
ETAA1
Ewing's tumor-associated antigen 1

Protein Summary
Description
Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723720, PubMed:27723717). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723720, PubMed:27723717). Probably only regulates a subset of ATR targets (PubMed:27723720, PubMed:27723717).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272342
  • ENSP00000272342
  • ENSG00000143971

Symbol
  • ETAA16
  • ETAA16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.7
small molecule perturbation
0.69
histone modification site profile
0.67
transcription factor perturbation
0.61
tissue sample
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.46   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.46   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
48.5
1
1
1
46.9
2
2
0
1.1
37.5
BMI-adjusted hip circumference
1
1
1
17.8
balding measurement
1
2
2
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
48.5
1
46.9
0
1.1
37.5
BMI-adjusted hip circumference
1
17.8
balding measurement
2
9.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ETAA1, ATR kinase activator
VGNC:10297
459289
Mouse
MGI:1915395
68145
Rat
RGD:1587340
316820
Dog
ETAA1, ATR kinase activator
VGNC:40486
474621
Horse
ETAA1, ATR kinase activator
VGNC:17692
100051184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ETAA1, ATR kinase activator
Mouse
Rat
Dog
ETAA1, ATR kinase activator
Horse
ETAA1, ATR kinase activator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NY74-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (30)
1 – 10 of 30
FBXO48
Tdark
Novelty:  0.53197799
Score:  0.792
Data Source:  STRINGDB
PNO1
Tbio
Novelty:  0.05311566
Score:  0.725
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.719
Data Source:  STRINGDB
CNRIP1
Tbio
Novelty:  0.06888531
Score:  0.714
Data Source:  STRINGDB
APLF
Tbio
Novelty:  0.01347476
Score:  0.692
Data Source:  STRINGDB
SPRED2
Tbio
Novelty:  0.04447225
Score:  0.688
Data Source:  STRINGDB
FAM84A
Tbio
Novelty:  0.16642071
Score:  0.615
Data Source:  STRINGDB
NUTM2F
Tdark
Novelty:  2.16748768
Score:  0.587
Data Source:  STRINGDB
CITED1
Tbio
Novelty:  0.01956689
Score:  0.573
Data Source:  STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.571
Data Source:  STRINGDB
Publication Statistics
PubMed Score  15.46

PubMed score by year
PubTator Score  5.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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