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Tbio
TUBA8
Tubulin alpha-8 chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316027
  • ENSP00000318575
  • ENSG00000183785
  • ENST00000330423
  • ENSP00000333326

Symbol
  • TUBAL2
  • CDCBM8
  • TUBAL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
histone modification site profile
0.76
disease perturbation
0.68
cell type or tissue
0.56
transcription factor
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.21   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
71.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
71.9
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peroxisomal biogenesis factor 26
710470
Mouse
MGI:1858225
53857
Rat
RGD:1566041
500377
Dog
tubulin alpha 8
VGNC:47987
486762
Horse
tubulin alpha 8
VGNC:24655
100054576
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peroxisomal biogenesis factor 26
Mouse
Rat
Dog
tubulin alpha 8
Horse
tubulin alpha 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NY65-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Reactome
Post-chaperonin tubulin folding pathway
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Post-chaperonin tubulin folding pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (117)
1 – 10 of 117
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.999999996
p_ni: 4e-9
Data Source: BioPlex
RPLP0
Tbio
Novelty: 0.00398127
p_int: 0.999999816
p_ni: 1.84e-7
Score: 0.606
Data Source: BioPlex,STRINGDB
RPL13
Tbio
Novelty: 0.0159486
p_int: 0.999999791
p_ni: 2.09e-7
Score: 0.34
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.999999184
p_ni: 8.16e-7
Score: 0.156
Data Source: BioPlex,STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.999997196
p_ni: 0.000002804
Score: 0.267
Data Source: BioPlex,STRINGDB
RBM4B
Tdark
Novelty: 0.33151475
p_int: 0.99999637
p_ni: 0.00000363
Data Source: BioPlex
MAK16
Tdark
Novelty: 0.07717917
p_int: 0.999994476
p_ni: 0.000005524
Data Source: BioPlex
TRMT10B
Tdark
Family: Enzyme
Novelty: 0.61950381
p_int: 0.999962044
p_ni: 0.000037955
p_wrong: 1e-9
Score: 0.152
Data Source: BioPlex,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.999889442
p_ni: 0.00010941
p_wrong: 0.000001148
Data Source: BioPlex
HIST1H1T
Tdark
Novelty: 0.01039464
p_int: 0.999855961
p_ni: 0.000144039
Data Source: BioPlex
Publication Statistics
PubMed Score  14.21

PubMed score by year
PubTator Score  6.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer