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Tbio
SLC2A8
Solute carrier family 2, facilitated glucose transporter member 8

Protein Summary
Description
Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity). This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373371
  • ENSP00000362469
  • ENSG00000136856

Symbol
  • GLUT8
  • GLUTX1
  • GLUT8
  • GLUTX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.88
histone modification site profile
0.78
cell line
0.73
cell type or tissue
0.69
small molecule perturbation
0.64


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.65   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.65   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
42.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 8
VGNC:8933
739414
Macaque
solute carrier family 2 member 8
701073
Mouse
MGI:1860103
56017
Rat
RGD:620611
85256
Dog
solute carrier family 2 member 8
VGNC:46344
480717
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 8
Macaque
solute carrier family 2 member 8
Mouse
Rat
Dog
solute carrier family 2 member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NY64-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Cellular hexose transport
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Cellular hexose transport
Clathrin-mediated endocytosis
Membrane Trafficking
SLC-mediated transmembrane transport
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (175)
1 – 10 of 175
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
p_int:  0.985969229
p_ni:  0.009226045
p_wrong:  0.004804726
Score:  0.198
Data Source:  BioPlex,STRINGDB
CD79A
Tbio
Novelty:  0.00118942
p_int:  0.908978523
p_ni:  0.055072435
p_wrong:  0.035949042
Score:  0.158
Data Source:  BioPlex,STRINGDB
DHRS9
Tbio
Family:  Enzyme
Novelty:  0.00256743
p_int:  0.895183299
p_ni:  0.104797872
p_wrong:  0.000018829
Score:  0.201
Data Source:  BioPlex,STRINGDB
PRKAG1
Tchem
Family:  Kinase
Novelty:  0.07735301
p_int:  0.871844852
p_ni:  0.082260118
p_wrong:  0.04589503
Score:  0.375
Data Source:  BioPlex,STRINGDB
KLK8
Tchem
Family:  Enzyme
Novelty:  0.00975023
p_int:  0.8647831
p_ni:  0.135199684
p_wrong:  0.000017216
Score:  0.239
Data Source:  BioPlex,STRINGDB
MINDY2
Tbio
Novelty:  0.46783751
p_int:  0.856737662
p_ni:  0.14321627
p_wrong:  0.000046068
Score:  0.173
Data Source:  BioPlex,STRINGDB
CHIA
Tchem
Family:  Enzyme
Novelty:  0.00181726
p_int:  0.82592908
p_ni:  0.060450209
p_wrong:  0.113620711
Score:  0.157
Data Source:  BioPlex,STRINGDB
ARMC6
Tdark
Novelty:  0.58706267
p_int:  0.816486722
p_ni:  0.11333881
p_wrong:  0.070174468
Score:  0.175
Data Source:  BioPlex,STRINGDB
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.81243581
p_ni:  0.117690766
p_wrong:  0.069873424
Data Source:  BioPlex
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.955
Data Source:  STRINGDB
Publication Statistics
PubMed Score  48.65

PubMed score by year
PubTator Score  17.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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