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Tbio
AATF
Protein AATF

Protein Summary
Description
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfer ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619387
  • ENSP00000477848
  • ENSG00000275700
  • ENST00000620004
  • ENSP00000481894
  • ENSG00000276072

Symbol
  • CHE1
  • DED
  • DED
  • BFR2
  • CHE1
  • CHE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
co-expressed gene
0.89
transcription factor binding site profile
0.89
hub protein
0.88
cellular component
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.85   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.85   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid volume
1
1
1
40.4
thyroid volume
1
1
1
40.4
1
1
1
40.4
1
1
1
40.4
macrophage inflammatory protein 1b measurement
1
1
1
29.5
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid volume
1
40.4
thyroid volume
1
40.4
1
40.4
1
40.4
macrophage inflammatory protein 1b measurement
1
29.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
apoptosis antagonizing transcription factor
717586
Mouse
MGI:1929608
56321
Rat
RGD:620685
114512
Dog
apoptosis antagonizing transcription factor
VGNC:37420
100856664
Horse
apoptosis antagonizing transcription factor
VGNC:14896
100057601
Species
Name
OMA
EggNOG
Inparanoid
Macaque
apoptosis antagonizing transcription factor
Mouse
Rat
Dog
apoptosis antagonizing transcription factor
Horse
apoptosis antagonizing transcription factor
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NY61-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
NRAGE signals death through JNK
Reactome
Signal Transduction
Reactome
p75 NTR receptor-mediated signalling
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
NRAGE signals death through JNK
Signal Transduction
p75 NTR receptor-mediated signalling
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (254)
1 – 10 of 254
NOL10
Tdark
Novelty: 0.27358884
p_int: 0.999853139
p_ni: 0.00014686
Score: 0.997
Data Source: BioPlex,STRINGDB
RPS2
Tbio
Novelty: 0.00412313
p_int: 0.93580729
p_ni: 0.06419271
Score: 0.215
Data Source: BioPlex,STRINGDB
H1FNT
Tdark
Novelty: 0.05593238
p_int: 0.881045048
p_ni: 0.118954952
Data Source: BioPlex
FGF8
Tbio
Novelty: 0.00155113
p_int: 0.879754375
p_ni: 0.120245625
Data Source: BioPlex
ZNF324B
Tdark
Family: TF
Novelty: 1.89922228
p_int: 0.849878821
p_ni: 0.150121179
Data Source: BioPlex
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.78502014
p_ni: 0.21497986
Data Source: BioPlex
DDX52
Tbio
Family: Enzyme
Novelty: 0.04618463
Score: 0.993
Data Source: STRINGDB
NOL6
Tbio
Novelty: 0.10002413
Score: 0.991
Data Source: STRINGDB
DDX56
Tbio
Family: Enzyme
Novelty: 0.03330582
Score: 0.989
Data Source: STRINGDB
NOC2L
Tbio
Novelty: 0.00226536
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.85

PubMed score by year
PubTator Score  56.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer