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Tchem
STK32B
Serine/threonine-protein kinase 32B

Protein Classes
Protein Summary
Description
This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282908
  • ENSP00000282908
  • ENSG00000152953
  • ENST00000510398
  • ENSP00000420984

Symbol
  • YANK2
  • STK32
  • STKG6
  • YANK2
  • HSA250839
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
kinase perturbation
0.91
histone modification site profile
0.76
PubMedID
0.76
phenotype
0.75


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL509032
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
97
self reported educational attainment
1
1
1
87.8
1
1
0
1.3
64.5
cognitive function measurement
1
1
1
61.5
smoking status measurement
1
1
1
57.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
97
self reported educational attainment
1
87.8
0
1.3
64.5
cognitive function measurement
1
61.5
smoking status measurement
1
57.5
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 32B
VGNC:12839
461094
Macaque
serine/threonine kinase 32B
711509
Mouse
MGI:1927552
64293
Rat
RGD:1306173
305431
Dog
serine/threonine kinase 32B
VGNC:46914
611147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 32B
Macaque
serine/threonine kinase 32B
Mouse
Rat
Dog
serine/threonine kinase 32B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NY57-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
EVC2
Tbio
Novelty: 0.01398469
Score: 0.803
Data Source: STRINGDB
FAM131C
Tdark
Novelty: 5.67998554
Score: 0.734
Data Source: STRINGDB
DIP2C
Tbio
Novelty: 0.18897853
Score: 0.727
Data Source: STRINGDB
MACROD2
Tbio
Family: Enzyme
Novelty: 0.02685751
Score: 0.682
Data Source: STRINGDB
CRMP1
Tbio
Family: Enzyme
Novelty: 0.01998451
Score: 0.635
Data Source: STRINGDB
MYO6
Tbio
Novelty: 0.01073438
Score: 0.6
Data Source: STRINGDB
GPR39
Tchem
Family: GPCR
Novelty: 0.01244607
Score: 0.596
Data Source: STRINGDB
PCED1B
Tdark
Family: Enzyme
Novelty: 0.42975161
Score: 0.565
Data Source: STRINGDB
DPYSL4
Tbio
Family: Enzyme
Novelty: 0.0449179
Score: 0.556
Data Source: STRINGDB
PDZRN4
Tdark
Novelty: 0.1881035
Score: 0.547
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.49

PubMed score by year
PubTator Score  3.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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