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Tclin
SCN3A
Sodium channel protein type 3 subunit alpha

Protein Classes
Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:24157691, PubMed:28235671, PubMed:29466837). May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells (By similarity). In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion (By similarity). Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283254
  • ENSP00000283254
  • ENSG00000153253
  • ENST00000360093
  • ENSP00000353206
  • ENST00000409101
  • ENSP00000386726

Symbol
  • KIAA1356
  • NAC3
  • NAC3
  • EIEE62
  • FFEVF4
  • Nav1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.9
molecular function
0.76
PubMedID
0.7
tissue
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.17   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.17   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 52
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 22
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
54.4
body mass index
1
1
1
52
waist-hip ratio
2
2
2
51.7
2
1
1
1.1
46.1
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
54.4
body mass index
1
52
waist-hip ratio
2
51.7
1
1.1
46.1
1
46.1
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 3
VGNC:14355
459699
Macaque
sodium voltage-gated channel alpha subunit 3
703178
Mouse
MGI:98249
20269
Rat
RGD:3635
497770
Dog
sodium voltage-gated channel alpha subunit 3
VGNC:45918
478772
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 3
Macaque
sodium voltage-gated channel alpha subunit 3
Mouse
Rat
Dog
sodium voltage-gated channel alpha subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NY46-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Protein-Protein Interactions (65)
1 – 10 of 65
SCN2A
Tclin
Family:  IC
Novelty:  0.0007317
Score:  0.993
Data Source:  STRINGDB
SCN4A
Tclin
Family:  IC
Novelty:  0.00185911
Score:  0.974
Data Source:  STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.974
Data Source:  STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
Score:  0.963
Data Source:  STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
Score:  0.963
Data Source:  STRINGDB
SCN9A
Tclin
Family:  IC
Novelty:  0.00169067
Score:  0.961
Data Source:  STRINGDB
SCN4B
Tbio
Family:  IC
Novelty:  0.02505113
Score:  0.957
Data Source:  STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.941
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.934
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.927
Data Source:  STRINGDB
Publication Statistics
PubMed Score  146.17

PubMed score by year
PubTator Score  61.16

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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