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Tbio
ASIC5
Acid-sensing ion channel 5

Protein Summary
Description
Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited by amiloride. This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000537611
  • ENSP00000442477
  • ENSG00000256394

Symbol
  • ACCN5
  • HINAC
  • INAC
  • ACCN5
  • HINAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
molecular function
0.76
cell line
0.63
tissue sample
0.58
tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.24   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.24   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
STOML3
Tbio
Novelty:  0.0587281
Score:  0.911
Data Source:  Reactome,STRINGDB
STOM
Tbio
Novelty:  0.00459891
Score:  0.905
Data Source:  STRINGDB
NCR1
Tbio
Novelty:  0.00282259
Score:  0.591
Data Source:  STRINGDB
CTSO
Tbio
Family:  Enzyme
Novelty:  0.09963965
Score:  0.581
Data Source:  STRINGDB
SLC10A2
Tclin
Family:  Transporter
Novelty:  0.0036213
Score:  0.509
Data Source:  STRINGDB
AK7
Tbio
Family:  Enzyme
Novelty:  0.0283556
Score:  0.472
Data Source:  STRINGDB
RBM46
Tbio
Novelty:  0.10180853
Score:  0.471
Data Source:  STRINGDB
SHISA5
Tbio
Novelty:  0.18952761
Score:  0.462
Data Source:  STRINGDB
SLC5A1
Tclin
Family:  Transporter
Novelty:  0.00113611
Score:  0.448
Data Source:  STRINGDB
NCR2
Tbio
Novelty:  0.00685029
Score:  0.44
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
51.4
1
1
1
30.2
1
1
1
5.3
Beta blocking agent use measurement
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
51.4
1
30.2
1
5.3
Beta blocking agent use measurement
1
1.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1929259
58170
Rat
RGD:69295
63866
Dog
acid sensing ion channel subunit family member 5
VGNC:38181
482664
Horse
acid sensing ion channel subunit family member 5
VGNC:15584
100062053
Anole lizard
acid sensing ion channel subunit family member 5
100562821
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
acid sensing ion channel subunit family member 5
Horse
acid sensing ion channel subunit family member 5
Anole lizard
acid sensing ion channel subunit family member 5
Publication Statistics
PubMed Score 8.24
PubMed score by year
PubTator Score 7.17
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title