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Tbio
DPP3
Dipeptidyl peptidase 3

Protein Summary
Description
Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin (PubMed:3233187, PubMed:1515063). Also cleaves Arg-Arg-beta-naphthylamide (in vitro) (PubMed:9425109, PubMed:3233187, PubMed:11209758). This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000530165
  • ENSP00000436941
  • ENSG00000254986
  • ENST00000541961
  • ENSP00000440502

Symbol
  • DPPIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.89
transcription factor perturbation
0.8
cellular component
0.77
tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.92   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.92   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (68)
1 – 10 of 68
BBS1
Tbio
Novelty:  0.00939439
p_int:  0.999864397
p_ni:  0.000135602
Score:  0.416
Data Source:  BioPlex,STRINGDB
KEAP1
Tclin
Novelty:  0.00062812
Score:  0.894
Data Source:  STRINGDB
RHPN2
Tbio
Novelty:  0.04808006
Score:  0.739
Data Source:  STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
Score:  0.739
Data Source:  STRINGDB
TPP2
Tchem
Family:  Enzyme
Novelty:  0.00803674
Score:  0.702
Data Source:  STRINGDB
NDUFS1
Tclin
Family:  Enzyme
Novelty:  0.0215624
Score:  0.695
Data Source:  STRINGDB
DPP7
Tchem
Family:  Enzyme
Novelty:  0.00644738
Score:  0.669
Data Source:  STRINGDB
NAGLU
Tbio
Family:  Enzyme
Novelty:  0.01033079
Score:  0.646
Data Source:  STRINGDB
MCMBP
Tbio
Novelty:  0.13330215
Score:  0.645
Data Source:  STRINGDB
AHCY
Tchem
Family:  Enzyme
Novelty:  0.00171812
Score:  0.636
Data Source:  STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
65.7
BMI-adjusted waist circumference
1
2
2
64.2
apolipoprotein B measurement
1
1
1
53.7
BMI-adjusted hip circumference
1
1
1
28.1
waist circumference
1
1
1
6.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
65.7
BMI-adjusted waist circumference
2
64.2
apolipoprotein B measurement
1
53.7
BMI-adjusted hip circumference
1
28.1
waist circumference
1
6.8
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1922471
75221
Rat
RGD:621127
114591
Dog
dipeptidyl peptidase 3
VGNC:40073
476011
Horse
dipeptidyl peptidase 3
VGNC:17293
100058485
Cow
dipeptidyl peptidase 3
VGNC:28187
510200
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
dipeptidyl peptidase 3
Horse
dipeptidyl peptidase 3
Cow
dipeptidyl peptidase 3
Publication Statistics
PubMed Score 150.92
PubMed score by year
PubTator Score 69.30
PubTator score by year