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Tbio
BTG4
Protein BTG4

Protein Summary
Description
Shows marked antiproliferative activity, being able to induce G(1) arrest. The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356018
  • ENSP00000348300
  • ENSG00000137707
  • ENST00000525791
  • ENSP00000432018

Symbol
  • PC3B
  • PC3B
  • APRO3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.67
tissue sample
0.53
cell line
0.44
chemical
0.41
histone modification site profile
0.39


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.64   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.64   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTG anti-proliferation factor 4
VGNC:3198
451538
Macaque
BTG anti-proliferation factor 4
709946
Mouse
MGI:1860140
56057
Rat
RGD:1308809
315650
Dog
BTG anti-proliferation factor 4
VGNC:53306
111089952
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTG anti-proliferation factor 4
Macaque
BTG anti-proliferation factor 4
Mouse
Rat
Dog
BTG anti-proliferation factor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NY30-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (40)
1 – 10 of 40
ZAR1L
Tdark
Novelty: 0.08793345
Score: 0.879
Data Source: STRINGDB
CNOT7
Tchem
Novelty: 0.04551853
Score: 0.863
Data Source: STRINGDB
BMP15
Tbio
Novelty: 0.00364888
Score: 0.794
Data Source: STRINGDB
CNOT8
Tbio
Novelty: 0.01700084
Score: 0.755
Data Source: STRINGDB
WEE2
Tbio
Family: Kinase
Novelty: 0.0422807
Score: 0.645
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.637
Data Source: STRINGDB
MOS
Tbio
Family: Kinase
Novelty: 0.05699356
Score: 0.602
Data Source: STRINGDB
ZAR1
Tbio
Novelty: 0.02026945
Score: 0.587
Data Source: STRINGDB
MSH4
Tbio
Novelty: 0.00838156
Score: 0.572
Data Source: STRINGDB
MARK3
Tchem
Family: Kinase
Novelty: 0.01304552
Score: 0.543
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.64

PubMed score by year
PubTator Score  7.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer