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Tbio
GALNT8
Probable polypeptide N-acetylgalactosaminyltransferase 8

Protein Summary
Description
Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252318
  • ENSP00000252318
  • ENSG00000130035

Symbol
  • GALNAC-T8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.49
cell line
0.48
metabolite
0.45
molecular function
0.45
gene perturbation
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.07   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.07   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
ATL3
Tbio
Novelty:  0.05295598
p_int:  0.999993665
p_ni:  0.000006335
Data Source:  BioPlex
ITPRIP
Tdark
Novelty:  0.27051709
p_int:  0.989496295
p_ni:  0.010503698
p_wrong:  6e-9
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.942161309
p_ni:  0.057838691
Data Source:  BioPlex
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.885929889
p_ni:  0.114068342
p_wrong:  0.000001769
Data Source:  BioPlex
TMEM164
Tdark
Novelty:  1.0284366
p_int:  0.868046635
p_ni:  0.051298873
p_wrong:  0.080654493
Data Source:  BioPlex
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.963
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.937
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.937
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.928
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
20
55.2
physical activity measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
20
55.2
physical activity measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
polypeptide N-acetylgalactosaminyltransferase 8
486734
Cow
polypeptide N-acetylgalactosaminyltransferase 8
540652
Pig
polypeptide N-acetylgalactosaminyltransferase 8
100522491
Species
Name
OMA
EggNOG
Inparanoid
Dog
polypeptide N-acetylgalactosaminyltransferase 8
Cow
polypeptide N-acetylgalactosaminyltransferase 8
Pig
polypeptide N-acetylgalactosaminyltransferase 8
Publication Statistics
PubMed Score 7.07
PubMed score by year
PubTator Score 3.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title