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Tbio
SLC39A1
Zinc transporter ZIP1

Protein Summary
Description
Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310483
  • ENSP00000309710
  • ENSG00000143570
  • ENST00000356205
  • ENSP00000348535
  • ENST00000368621
  • ENSP00000357610
  • ENST00000368623
  • ENSP00000357612
  • ENST00000617697
  • ENSP00000479421
  • ENST00000621013
  • ENSP00000484182

Symbol
  • IRT1
  • ZIP1
  • ZIRTL
  • ZIP1
  • ZIRTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.74
transcription factor binding site profile
0.74
tissue sample
0.71
histone modification site profile
0.68
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.2   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.2   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0