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Tbio
CLEC5A
C-type lectin domain family 5 member A

Protein Summary
Description
Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity). (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123). The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526). This interaction does not result in viral entry, but stimulates proinflammatory cytokine release (PubMed:18496526). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000546910
  • ENSP00000449999
  • ENSG00000258227

Symbol
  • CLECSF5
  • MDL1
  • MDL1
  • MDL-1
  • CLECSF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
gene perturbation
0.75
cell type or tissue
0.62
tissue sample
0.59
biological process
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.5   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.5   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
2
2
3
95.8
bitter alcoholic beverage consumption measurement
1
1
1
42.3
tea consumption measurement
1
1
1
40.7
body mass index
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of bitter taste
3
95.8
bitter alcoholic beverage consumption measurement
1
42.3
tea consumption measurement
1
40.7
body mass index
1
15.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 5A
VGNC:7365
741844
Macaque
C-type lectin domain containing 5A
695425
Mouse
MGI:1345151
23845
Rat
RGD:1584755
679787
Dog
C-type lectin domain containing 5A
VGNC:39334
609161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain containing 5A
Macaque
C-type lectin domain containing 5A
Mouse
Rat
Dog
C-type lectin domain containing 5A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NY25-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
DAP12 interactions (R-HSA-2172127)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DAP12 interactions
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
DAP12 interactions
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (173)
1 – 10 of 173
CD276
Tbio
Novelty:  0.00084069
p_int:  0.999501187
p_ni:  0.000498813
Score:  0.209
Data Source:  BioPlex,STRINGDB
TMBIM6
Tbio
Novelty:  0.00151958
p_int:  0.998723362
p_ni:  0.001276615
p_wrong:  2.4e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.996812515
p_ni:  0.003187485
Data Source:  BioPlex
TSPAN6
Tbio
Novelty:  0.11515803
p_int:  0.989473542
p_ni:  0.002558156
p_wrong:  0.007968302
Score:  0.204
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.972720674
p_ni:  0.027279326
Data Source:  BioPlex
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.970895616
p_ni:  0.029104384
Data Source:  BioPlex
CHCHD6
Tbio
Novelty:  0.12379343
p_int:  0.963406525
p_ni:  0.036593475
Score:  0.261
Data Source:  BioPlex,STRINGDB
MTX3
Tdark
Novelty:  0.06082176
p_int:  0.963166679
p_ni:  0.036833319
p_wrong:  1e-9
Data Source:  BioPlex
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.961148782
p_ni:  0.037970582
p_wrong:  0.000880636
Score:  0.239
Data Source:  BioPlex,STRINGDB
CST6
Tbio
Novelty:  0.02811473
p_int:  0.916684888
p_ni:  0.082543247
p_wrong:  0.000771864
Data Source:  BioPlex
Publication Statistics
PubMed Score  70.50

PubMed score by year
PubTator Score  24.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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