Tbio CLEC5A C-type lectin domain family 5 member A

Protein Summary

Description

Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity). (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123). The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526). This interaction does not result in viral entry, but stimulates proinflammatory cytokine release (PubMed:18496526). This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NY25
• Q52M11
• Q9UKQ0

Gene Name

• CLEC5A

Ensembl ID

• ENST00000546910
• ENSP00000449999
• ENSG00000258227

Symbol

• CLECSF5
• MDL1
• MDL1
• MDL-1
• CLECSF5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
gene perturbation	0.75
cell type or tissue	0.62
tissue sample	0.59
biological process	0.55

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.5   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.5   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sensory perception of bitter taste	GO_0050913	2	2	3		95.8
bitter alcoholic beverage consumption measurement	EFO_0010092	1	1	1		42.3
tea consumption measurement	EFO_0010091	1	1	1		40.7
body mass index	EFO_0004340	1	1	1		15.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sensory perception of bitter taste	GO_0050913	3		95.8
bitter alcoholic beverage consumption measurement	EFO_0010092	1		42.3
tea consumption measurement	EFO_0010091	1		40.7
body mass index	EFO_0004340	1		15.5

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	C-type lectin domain containing 5A	VGNC:7365	741844
Macaque	C-type lectin domain containing 5A		695425
Mouse	C-type lectin domain family 5, member a	MGI:1345151	23845
Rat	C-type lectin domain containing 5A	RGD:1584755	679787
Dog	C-type lectin domain containing 5A	VGNC:39334	609161

Species	Name	OMA	EggNOG	Inparanoid
Chimp	C-type lectin domain containing 5A
Macaque	C-type lectin domain containing 5A
Mouse	C-type lectin domain family 5, member a
Rat	C-type lectin domain containing 5A
Dog	C-type lectin domain containing 5A

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NY25-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (4)

Reactome (4)

DAP12 interactions (R-HSA-2172127)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DAP12 interactions	92 targets	R-HSA-2172127
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
DAP12 interactions	92 targets	R-HSA-2172127
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Gene Ontology Terms (17)

Functions (2)

Components (6)

Processes (9)

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1 – 2 of 2

GO Term	Evidence	Assigned by
virus receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
carbohydrate binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (173)

Explore Interacting Targets

1 – 10 of 173

• See Interactions on String-DB

CD276

Tbio

Novelty:  0.00084069

p_int:  0.999501187

p_ni:  0.000498813

Score:  0.209

Data Source:  BioPlex,STRINGDB

TMBIM6

Tbio

Novelty:  0.00151958

p_int:  0.998723362

p_ni:  0.001276615

p_wrong:  2.4e-8

Score:  0.183

Data Source:  BioPlex,STRINGDB

TUBB1

Tclin

Novelty:  0.02806117

p_int:  0.996812515

p_ni:  0.003187485

Data Source:  BioPlex

TSPAN6

Tbio

Novelty:  0.11515803

p_int:  0.989473542

p_ni:  0.002558156

p_wrong:  0.007968302

Score:  0.204

Data Source:  BioPlex,STRINGDB

REEP5

Tbio

Novelty:  0.00160455

p_int:  0.972720674

p_ni:  0.027279326

Data Source:  BioPlex

ECSIT

Tbio

Novelty:  0.04690184

p_int:  0.970895616

p_ni:  0.029104384

Data Source:  BioPlex

CHCHD6

Tbio

Novelty:  0.12379343

p_int:  0.963406525

p_ni:  0.036593475

Score:  0.261

Data Source:  BioPlex,STRINGDB

MTX3

Tdark

Novelty:  0.06082176

p_int:  0.963166679

p_ni:  0.036833319

p_wrong:  1e-9

Data Source:  BioPlex

REEP6

Tbio

Novelty:  0.10645981

p_int:  0.961148782

p_ni:  0.037970582

p_wrong:  0.000880636

Score:  0.239

Data Source:  BioPlex,STRINGDB

CST6

Tbio

Novelty:  0.02811473

p_int:  0.916684888

p_ni:  0.082543247

p_wrong:  0.000771864

Data Source:  BioPlex

Publication Statistics

PubMed Score  70.50

PubMed score by year

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PubTator Score  24.51

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunity
Innate immunity

GWAS Trait Find Similar Targets

No Header	No Header
bitter alcoholic beverage consumption measurement
body mass index
sensory perception of bitter taste
tea consumption measurement

MGI Phenotype Find Similar Targets

No Header	No Header
immune system phenotype
skeleton phenotype