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Tbio
GAR1
H/ACA ribonucleoprotein complex subunit 1

Protein Summary
Description
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nuc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226796
  • ENSP00000226796
  • ENSG00000109534
  • ENST00000394631
  • ENSP00000378127

Symbol
  • NOLA1
  • NOLA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
hub protein
0.79
protein complex
0.79
histone modification site profile
0.74
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (270)
GEMIN5
Tbio
Novelty:  0.03683801
p_int:  0.999990493
p_ni:  0.000009507
Score:  0.509
Data Source:  BioPlex,STRINGDB
SHQ1
Tbio
Novelty:  0.09779957
p_int:  0.999953997
p_ni:  0.000046001
p_wrong:  2e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
DKC1
Tbio
Novelty:  0.00352181
p_int:  0.999949871
p_ni:  0.000050129
Score:  0.999
Data Source:  BioPlex,STRINGDB
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
p_int:  0.99991938
p_ni:  0.000080619
p_wrong:  1e-9
Score:  0.398
Data Source:  BioPlex,STRINGDB
NOP10
Tbio
Novelty:  0.0188462
p_int:  0.993637832
p_ni:  0.006357665
p_wrong:  0.000004502
Score:  0.999
Data Source:  BioPlex,STRINGDB
GSTA1
Tchem
Family:  Enzyme
Novelty:  0.00308319
p_int:  0.974632168
p_ni:  0.018340844
p_wrong:  0.007026987
Score:  0.183
Data Source:  BioPlex,STRINGDB
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
p_int:  0.973248583
p_ni:  0.026751417
Score:  0.513
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.973019647
p_ni:  0.000397805
p_wrong:  0.026582549
Score:  0.219
Data Source:  BioPlex,STRINGDB
ZCRB1
Tdark
Novelty:  0.37592387
p_int:  0.936455725
p_ni:  0.063544259
p_wrong:  1.6e-8
Score:  0.441
Data Source:  BioPlex,STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.902206415
p_ni:  0.097793541
p_wrong:  4.4e-8
Score:  0.293
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
84.5
lymphocyte count
2
1
2
77.3
2
2
0
1.2
71.5
atrophic macular degeneration
1
2
0
2.4
71.5
2
2
0
1.3
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
84.5
lymphocyte count
2
77.3
0
1.2
71.5
atrophic macular degeneration
0
2.4
71.5
0
1.3
71.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GAR1 ribonucleoprotein
VGNC:2006
461433
Macaque
GAR1 ribonucleoprotein
697982
Mouse
MGI:1930948
68147
Rat
RGD:1563995
499709
Dog
GAR1 ribonucleoprotein
610515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GAR1 ribonucleoprotein
Macaque
GAR1 ribonucleoprotein
Mouse
Rat
Dog
GAR1 ribonucleoprotein
Publication Statistics
PubMed Score 5.17
PubMed score by year
PubTator Score 16.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title