Tbio SAGE1 Sarcoma antigen 1

Protein Summary

Description

This gene belongs to a class of genes that are activated in tumors. These genes are expressed in tumors of different histologic types but not in normal tissues, except for spermatogenic cells and, for some, placenta. The proteins encoded by these genes appear to be strictly tumor specific, and hence may be excellent sources of antigens for cancer immunotherapy. This gene is expressed in sarcomas. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NXZ1
• Q5JNW0

Gene Name

• SAGE1

Ensembl ID

• ENST00000324447
• ENSP00000323191
• ENSG00000181433
• ENST00000370709
• ENSP00000359743

Symbol

• SAGE
• CT14
• SAGE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.85
cell line	0.59
tissue sample	0.5
biological term	0.33
cellular component	0.33

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Sarcoma Antigen 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Sarcoma Antigen 1

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Sarcoma Antigen 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.13   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.13   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0