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Tbio
DNAJB12
DnaJ homolog subfamily B member 12

Protein Summary
Description
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:21150129, PubMed:21148293). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). (Microbial infection) In case of infection by polyoma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000444643
  • ENSP00000403313
  • ENSG00000148719

Symbol
  • DJ10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor binding site profile
0.95
interacting protein
0.84
transcription factor
0.73
microRNA
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
46.5
refractive error measurement
2
2
1
5.7
32.8
serum gamma-glutamyl transferase measurement
1
1
1
29
mathematical ability
1
1
1
24.5
age at onset
1
1
0
5.7
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
46.5
refractive error measurement
1
5.7
32.8
serum gamma-glutamyl transferase measurement
1
29
mathematical ability
1
24.5
age at onset
0
5.7
21.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B12
VGNC:12303
450887
Mouse
MGI:1931881
56709
Rat
RGD:1359677
294513
Dog
DnaJ heat shock protein family (Hsp40) member B12
489039
Horse
DnaJ heat shock protein family (Hsp40) member B12
100063614
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B12
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B12
Horse
DnaJ heat shock protein family (Hsp40) member B12
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NXW2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (57)
1 – 10 of 57
HSPA2
Tchem
Novelty:  0.01696667
Score:  0.957
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.919
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.862
Data Source:  STRINGDB
HSPH1
Tbio
Novelty:  0.01617555
Score:  0.744
Data Source:  STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.722
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.71
Data Source:  STRINGDB
HSPA1L
Tbio
Novelty:  0.01658161
Score:  0.693
Data Source:  STRINGDB
SGTA
Tbio
Novelty:  0.01488022
Score:  0.69
Data Source:  STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.668
Data Source:  STRINGDB
HSPA13
Tbio
Novelty:  0.03895652
Score:  0.639
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.85

PubMed score by year
PubTator Score  2.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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