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Tbio
KCTD5
BTB/POZ domain-containing protein KCTD5

Protein Summary
Description
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301738
  • ENSP00000301738
  • ENSG00000167977
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.85
histone modification site profile
0.81
virus perturbation
0.76
transcription factor
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.82   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.82   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 5
VGNC:13724
453840
Mouse
MGI:1916509
69259
Rat
RGD:1304990
287109
Dog
potassium channel tetramerization domain containing 5
VGNC:42309
490058
Cow
potassium channel tetramerization domain containing 5
VGNC:30513
100125308
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 5
Mouse
Rat
Dog
potassium channel tetramerization domain containing 5
Cow
potassium channel tetramerization domain containing 5
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NXV2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (43)
1 – 10 of 43
KCTD17
Tbio
Novelty: 0.12105733
p_int: 0.999987226
p_ni: 0.000012774
Score: 0.828
Data Source: BioPlex,STRINGDB
PDZK1P1
Tdark
p_int: 0.999688811
p_ni: 0.000311189
Data Source: BioPlex
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.998870998
p_ni: 0.001129002
Score: 0.208
Data Source: BioPlex,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
p_int: 0.811108887
p_ni: 0.18888768
p_wrong: 0.000003432
Data Source: BioPlex
KCND2
Tclin
Family: IC
Novelty: 0.00297203
p_int: 0.798166348
p_ni: 0.20183353
p_wrong: 1.22e-7
Score: 0.871
Data Source: BioPlex,STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.857
Data Source: STRINGDB
PDZK1
Tbio
Novelty: 0.01129974
Score: 0.8
Data Source: STRINGDB
KCTD11
Tbio
Novelty: 0.11239142
Score: 0.715
Data Source: STRINGDB
GORASP2
Tbio
Novelty: 0.02121907
Score: 0.662
Data Source: STRINGDB
KCTD20
Tdark
Novelty: 0.47655751
Score: 0.661
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.82

PubMed score by year
PubTator Score  6.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer