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Tbio
ING3
Inhibitor of growth protein 3

Protein Summary
Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315870
  • ENSP00000320566
  • ENSG00000071243
  • ENST00000339121
  • ENSP00000341697
  • ENST00000427726
  • ENSP00000410406

Symbol
  • Eaf4
  • ING2
  • MEAF4
  • p47ING3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
protein domain
0.92
transcription factor binding site profile
0.86
cellular component
0.8
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.75   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.75   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (126)
1 – 10 of 126
FOXR2
Tbio
Family: TF
Novelty: 0.06548862
p_int: 0.999999756
p_ni: 2.43e-7
p_wrong: 1e-9
Score: 0.697
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999999672
p_ni: 3.28e-7
Score: 0.97
Data Source: BioPlex,STRINGDB
JADE2
Tbio
Family: Epigenetic
Novelty: 0.19820849
p_int: 0.999999523
p_ni: 4.77e-7
Score: 0.625
Data Source: BioPlex,STRINGDB
MEAF6
Tbio
Novelty: 0.0914094
p_int: 0.999999335
p_ni: 6.64e-7
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
MYCL
Tbio
Family: TF
Novelty: 0.0034508
p_int: 0.999999259
p_ni: 7.41e-7
Score: 0.749
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999990871
p_ni: 0.000009129
Score: 0.536
Data Source: BioPlex,STRINGDB
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.999988239
p_ni: 0.000011761
Score: 0.981
Data Source: BioPlex,STRINGDB
DMAP1
Tbio
Family: Enzyme
Novelty: 0.03152166
p_int: 0.999973314
p_ni: 0.000026686
Score: 0.986
Data Source: BioPlex,STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
p_int: 0.999973038
p_ni: 0.000026962
Score: 0.99
Data Source: BioPlex,STRINGDB
MRGBP
Tbio
Novelty: 0.09537142
p_int: 0.999954874
p_ni: 0.000045126
Score: 0.993
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  67.75

PubMed score by year
PubTator Score  16.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer