You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BABAM2
BRISC and BRCA1-A complex member 2

Protein Summary
Description
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342045
  • ENSP00000339371
  • ENSG00000158019
  • ENST00000344773
  • ENSP00000343412
  • ENST00000361704
  • ENSP00000354699
  • ENST00000379624
  • ENSP00000368945
  • ENST00000379632
  • ENSP00000368953

Symbol
  • BRCC45
  • BRE
  • BRE
  • BRCC4
  • BRCC45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.45   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.45   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (120)
1 – 10 of 120
BABAM1
Tbio
Novelty:  0.03812501
p_int:  0.999999045
p_ni:  9.54e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.999926392
p_ni:  0.000073608
Score:  0.692
Data Source:  BioPlex,STRINGDB
SHMT2
Tchem
Family:  Enzyme
Novelty:  0.00234505
p_int:  0.999671211
p_ni:  0.000328789
Score:  0.987
Data Source:  BioPlex,STRINGDB
DNAJC25
Tdark
Novelty:  1.55044803
p_int:  0.999404483
p_ni:  0.000595516
Data Source:  BioPlex
C9orf85
Tdark
Novelty:  4.61061386
p_int:  0.997009412
p_ni:  0.002988429
p_wrong:  0.000002159
Data Source:  BioPlex
CHI3L1
Tbio
Family:  Enzyme
Novelty:  0.00119387
p_int:  0.984076198
p_ni:  0.015917857
p_wrong:  0.000005944
Score:  0.516
Data Source:  BioPlex,STRINGDB
C2orf73
Tdark
Novelty:  0.8689571
p_int:  0.983074203
p_ni:  0.016925797
Data Source:  BioPlex
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.917810418
p_ni:  0.082189564
p_wrong:  1.8e-8
Data Source:  BioPlex
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.894169259
p_ni:  0.105657905
p_wrong:  0.000172836
Data Source:  BioPlex
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.88432934
p_ni:  0.115666069
p_wrong:  0.000004591
Data Source:  BioPlex
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
14
14
97
serum gamma-glutamyl transferase measurement
2
6
6
95.5
hematocrit
3
3
3
91.4
hair color
1
3
0
1.1
91
C-reactive protein measurement
2
6
6
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
14
97
serum gamma-glutamyl transferase measurement
6
95.5
hematocrit
3
91.4
hair color
0
1.1
91
C-reactive protein measurement
6
87.8
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BRISC and BRCA1 A complex member 2
702365
Mouse
MGI:1333875
107976
Rat
RGD:735111
362704
Dog
BRISC and BRCA1 A complex member 2
VGNC:38357
475711
Horse
BRISC and BRCA1 A complex member 2
VGNC:15749
100054872
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BRISC and BRCA1 A complex member 2
Mouse
Rat
Dog
BRISC and BRCA1 A complex member 2
Horse
BRISC and BRCA1 A complex member 2
Publication Statistics
PubMed Score 224.45
PubMed score by year
PubTator Score 20.67
PubTator score by year