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Tbio
MCM9
DNA helicase MCM9

Protein Summary
Description
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as an helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). The protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316068
  • ENSP00000312870
  • ENSG00000111877
  • ENST00000316316
  • ENSP00000314505
  • ENST00000619706
  • ENSP00000480469

Symbol
  • C6orf61
  • MCMDC1
  • ODG4
  • MCMDC1
  • C6orf61
  • dJ329L24.1
  • dJ329L24.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
gene perturbation
0.83
virus perturbation
0.79
tissue sample
0.63
cell type or tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.15   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.15   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (154)
MCM8
Tbio
Family:  Enzyme
Novelty:  0.02602136
p_int:  0.999998896
p_ni:  0.000001103
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.999983665
p_ni:  0.000016333
p_wrong:  2e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.999979088
p_ni:  0.00002091
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
NELFA
Tbio
Novelty:  0.09727823
p_int:  0.99798012
p_ni:  0.002012835
p_wrong:  0.000007045
Score:  0.187
Data Source:  BioPlex,STRINGDB
MLH1
Tbio
Novelty:  0.00034212
p_int:  0.995345865
p_ni:  0.00430999
p_wrong:  0.000344145
Score:  0.687
Data Source:  BioPlex,STRINGDB
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.994903706
p_ni:  0.005089825
p_wrong:  0.00000647
Data Source:  BioPlex
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.980855496
p_ni:  0.018562819
p_wrong:  0.000581685
Data Source:  BioPlex
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.976616393
p_ni:  0.022433971
p_wrong:  0.000949636
Data Source:  BioPlex
CHIC1
Tdark
Novelty:  0.06718561
p_int:  0.934739424
p_ni:  0.061905739
p_wrong:  0.003354837
Data Source:  BioPlex
FAF2
Tbio
Novelty:  0.03048598
p_int:  0.923371307
p_ni:  0.076608023
p_wrong:  0.00002067
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
5
5
5
98
mean platelet volume
3
2
3
87.7
self reported educational attainment
3
4
4
79.9
mathematical ability
2
2
2
69.6
dehydroepiandrosterone sulphate measurement
1
1
2
51.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
5
98
mean platelet volume
3
87.7
self reported educational attainment
4
79.9
mathematical ability
2
69.6
dehydroepiandrosterone sulphate measurement
2
51.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918817
71567
Rat
RGD:1560557
499437
Dog
minichromosome maintenance 9 homologous recombination repair factor
VGNC:43089
484104
Cow
minichromosome maintenance 9 homologous recombination repair factor
VGNC:31315
100139498
Opossum
minichromosome maintenance 9 homologous recombination repair factor
100030189
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
minichromosome maintenance 9 homologous recombination repair factor
Cow
minichromosome maintenance 9 homologous recombination repair factor
Opossum
minichromosome maintenance 9 homologous recombination repair factor
Publication Statistics
PubMed Score 29.15
PubMed score by year
PubTator Score 15.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title