Tbio MCM9 DNA helicase MCM9

Protein Summary

Description

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as an helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9NXL9
• B4DR30
• B9DI77
• Q2KHJ0
• Q8N5S5
• Q9HCV5
• hMCM9

Gene Name

• MCM9

Ensembl ID

• ENST00000316068
• ENSP00000312870
• ENSG00000111877
• ENST00000316316
• ENSP00000314505
• ENST00000619706
• ENSP00000480469

Symbol

• C6orf61
• MCMDC1
• ODG4
• MCMDC1
• C6orf61
• dJ329L24.1
• dJ329L24.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
gene perturbation	0.83
virus perturbation	0.79
tissue sample	0.63
cell type or tissue	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Dna Helicase Mcm9

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Dna Helicase Mcm9

Protein / Hydrolase / Dna Helicase Mcm9

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Dna Helicase Mcm9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.77   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.77   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0