Tbio MCM9 DNA helicase MCM9

Protein Summary

Description

Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as an helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9NXL9
• B4DR30
• B9DI77
• Q2KHJ0
• Q8N5S5
• Q9HCV5
• hMCM9

Gene Name

• MCM9

Ensembl ID

• ENST00000316068
• ENSP00000312870
• ENSG00000111877
• ENST00000316316
• ENSP00000314505
• ENST00000619706
• ENSP00000480469

Symbol

• C6orf61
• MCMDC1
• ODG4
• MCMDC1
• C6orf61
• dJ329L24.1
• dJ329L24.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
gene perturbation	0.83
virus perturbation	0.79
tissue sample	0.63
cell type or tissue	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Dna Helicase Mcm9

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Dna Helicase Mcm9

Protein / Hydrolase / Dna Helicase Mcm9

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Dna Helicase Mcm9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.15   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 81   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.15   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (154)

Explore Interacting Targets

1 – 10 of 154

• See Interactions on String-DB

MCM8

Tbio

Family:  Enzyme

Novelty:  0.02602136

p_int:  0.999998896

p_ni:  0.000001103

p_wrong:  1e-9

Score:  0.988

Data Source:  BioPlex,STRINGDB

VWA5A

Tbio

Novelty:  0.0802354

p_int:  0.999983665

p_ni:  0.000016333

p_wrong:  2e-9

Score:  0.313

Data Source:  BioPlex,STRINGDB

PSG8

Tdark

Novelty:  0.1446257

p_int:  0.999979088

p_ni:  0.00002091

p_wrong:  2e-9

Score:  0.2

Data Source:  BioPlex,STRINGDB

NELFA

Tbio

Novelty:  0.09727823

p_int:  0.99798012

p_ni:  0.002012835

p_wrong:  0.000007045

Score:  0.187

Data Source:  BioPlex,STRINGDB

MLH1

Tbio

Novelty:  0.00034212

p_int:  0.995345865

p_ni:  0.00430999

p_wrong:  0.000344145

Score:  0.687

Data Source:  BioPlex,STRINGDB

THBS3

Tbio

Novelty:  0.01915634

p_int:  0.994903706

p_ni:  0.005089825

p_wrong:  0.00000647

Data Source:  BioPlex

PLAUR

Tchem

Family:  Enzyme

Novelty:  0.00087642

p_int:  0.980855496

p_ni:  0.018562819

p_wrong:  0.000581685

Data Source:  BioPlex

HNRNPLL

Tbio

Novelty:  0.0498467

p_int:  0.976616393

p_ni:  0.022433971

p_wrong:  0.000949636

Data Source:  BioPlex

CHIC1

Tdark

Novelty:  0.06718561

p_int:  0.934739424

p_ni:  0.061905739

p_wrong:  0.003354837

Data Source:  BioPlex

FAF2

Tbio

Novelty:  0.03048598

p_int:  0.923371307

p_ni:  0.076608023

p_wrong:  0.00002067

Score:  0.157

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

WikiPathways (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Ciliary landscape	642 targets	WP4352_r102218

Name	Explore in Pharos	Explore in Source
Ciliary landscape	642 targets	WP4352_r102218

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (19)

Functions (9)

Components (3)

Processes (7)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	UniProtKB
MutLbeta complex binding	Inferred from Direct Assay (IDA)	UniProtKB
MutSalpha complex binding	Inferred from Direct Assay (IDA)	UniProtKB
MutSbeta complex binding	Inferred from Direct Assay (IDA)	UniProtKB
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
DNA helicase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	5	5	5		98
mean platelet volume	EFO_0004584	3	2	3		87.7
self reported educational attainment	EFO_0004784	3	4	4		79.9
mathematical ability	EFO_0004875	2	2	2		69.6
dehydroepiandrosterone sulphate measurement	EFO_0007001	1	1	2		51.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	5		98
mean platelet volume	EFO_0004584	3		87.7
self reported educational attainment	EFO_0004784	4		79.9
mathematical ability	EFO_0004875	2		69.6
dehydroepiandrosterone sulphate measurement	EFO_0007001	2		51.7

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Chromosome
Complete proteome
DNA damage
DNA repair
DNA-binding
Helicase
Hydrolase
Nucleotide-binding

GWAS Trait Find Similar Targets

No Header	No Header
chloride measurement
dehydroepiandrosterone sulphate measurement
electrocardiography
household income
intelligence
mathematical ability
mean platelet volume
schizophrenia
self reported educational attainment
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
neoplasm
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	minichromosome maintenance 9 homologous recombination repair factor	MGI:1918817	71567
Rat	minichromosome maintenance 9 homologous recombination repair factor	RGD:1560557	499437
Dog	minichromosome maintenance 9 homologous recombination repair factor	VGNC:43089	484104
Cow	minichromosome maintenance 9 homologous recombination repair factor	VGNC:31315	100139498
Opossum	minichromosome maintenance 9 homologous recombination repair factor		100030189

Species	Name	OMA	EggNOG	Inparanoid
Mouse	minichromosome maintenance 9 homologous recombination repair factor
Rat	minichromosome maintenance 9 homologous recombination repair factor
Dog	minichromosome maintenance 9 homologous recombination repair factor
Cow	minichromosome maintenance 9 homologous recombination repair factor
Opossum	minichromosome maintenance 9 homologous recombination repair factor

Publication Statistics

PubMed Score 29.15

PubMed score by year

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PubTator Score 15.35

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (12)

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10

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PMID	Year	Title