Protein Summary
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as an helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). The protei ...more
- ENST00000316068
- ENSP00000312870
- ENSG00000111877
- ENST00000316316
- ENSP00000314505
- ENST00000619706
- ENSP00000480469
- C6orf61
- MCMDC1
- ODG4
- MCMDC1
- C6orf61
- dJ329L24.1
- dJ329L24.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.93 | ||
gene perturbation | 0.83 | ||
virus perturbation | 0.79 | ||
tissue sample | 0.63 | ||
cell type or tissue | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.15 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.15 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (154)
MCM8
Family: Enzyme
Novelty: 0.02602136
p_int: 0.999998896
p_ni: 0.000001103
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
VWA5A
Novelty: 0.0802354
p_int: 0.999983665
p_ni: 0.000016333
p_wrong: 2e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
PSG8
Novelty: 0.1446257
p_int: 0.999979088
p_ni: 0.00002091
p_wrong: 2e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
NELFA
Novelty: 0.09727823
p_int: 0.99798012
p_ni: 0.002012835
p_wrong: 0.000007045
Score: 0.187
Data Source: BioPlex,STRINGDB
MLH1
Novelty: 0.00034212
p_int: 0.995345865
p_ni: 0.00430999
p_wrong: 0.000344145
Score: 0.687
Data Source: BioPlex,STRINGDB
THBS3
Novelty: 0.01915634
p_int: 0.994903706
p_ni: 0.005089825
p_wrong: 0.00000647
Data Source: BioPlex
PLAUR
Family: Enzyme
Novelty: 0.00087642
p_int: 0.980855496
p_ni: 0.018562819
p_wrong: 0.000581685
Data Source: BioPlex
HNRNPLL
Novelty: 0.0498467
p_int: 0.976616393
p_ni: 0.022433971
p_wrong: 0.000949636
Data Source: BioPlex
CHIC1
Novelty: 0.06718561
p_int: 0.934739424
p_ni: 0.061905739
p_wrong: 0.003354837
Data Source: BioPlex
FAF2
Novelty: 0.03048598
p_int: 0.923371307
p_ni: 0.076608023
p_wrong: 0.00002067
Score: 0.157
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
WikiPathways (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
WikiPathways | Ciliary landscape | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Ciliary landscape | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (9)
Components (3)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 5 | 5 | 98 | |||||
mean platelet volume | 3 | 2 | 3 | 87.7 | |||||
self reported educational attainment | 3 | 4 | 4 | 79.9 | |||||
mathematical ability | 2 | 2 | 2 | 69.6 | |||||
dehydroepiandrosterone sulphate measurement | 1 | 1 | 2 | 51.7 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 5 | 98 | |||||
mean platelet volume | 3 | 87.7 | |||||
self reported educational attainment | 4 | 79.9 | |||||
mathematical ability | 2 | 69.6 | |||||
dehydroepiandrosterone sulphate measurement | 2 | 51.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:1918817 | 71567 | ||||||
Rat | RGD:1560557 | 499437 | ||||||
Dog | minichromosome maintenance 9 homologous recombination repair factor | VGNC:43089 | 484104 | |||||
Cow | minichromosome maintenance 9 homologous recombination repair factor | VGNC:31315 | 100139498 | |||||
Opossum | minichromosome maintenance 9 homologous recombination repair factor | 100030189 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | minichromosome maintenance 9 homologous recombination repair factor | |||||
Cow | minichromosome maintenance 9 homologous recombination repair factor | |||||
Opossum | minichromosome maintenance 9 homologous recombination repair factor | |||||
Publication Statistics
PubMed Score 29.15
PubMed score by year
PubTator Score 15.35
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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