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Tbio
SIDT1
SID1 transmembrane family member 1

Protein Summary
Description
In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264852
  • ENSP00000264852
  • ENSG00000072858
  • ENST00000393830
  • ENSP00000377416

Symbol
  • SID1
  • SID-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
cell type or tissue
0.68
PubMedID
0.64
transcription factor
0.59
transcription factor binding site profile
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.95   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.95   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
4
2
0
1.1
94.4
mean platelet volume
3
2
3
85.2
1
1
1
43.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
94.4
mean platelet volume
3
85.2
1
43.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SID1 transmembrane family member 1
VGNC:7123
470883
Macaque
SID1 transmembrane family member 1
709487
Mouse
MGI:2443155
320007
Rat
RGD:1559616
288109
Dog
SID1 transmembrane family member 1
VGNC:46165
100685132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SID1 transmembrane family member 1
Macaque
SID1 transmembrane family member 1
Mouse
Rat
Dog
SID1 transmembrane family member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NXL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (24)
1 – 10 of 24
UNC119
Tchem
Novelty: 0.00396292
Score: 0.713
Data Source: STRINGDB
ERI1
Tbio
Family: Enzyme
Novelty: 0.00959105
Score: 0.696
Data Source: STRINGDB
IGDCC3
Tdark
Novelty: 0.01192143
Score: 0.695
Data Source: STRINGDB
TMEM8A
Tdark
Novelty: 0.15724279
Score: 0.628
Data Source: STRINGDB
ACER2
Tchem
Family: Enzyme
Novelty: 0.040885
Score: 0.59
Data Source: STRINGDB
DICER1
Tbio
Family: Enzyme
Novelty: 0.000306
Score: 0.58
Data Source: STRINGDB
ACER1
Tbio
Family: Enzyme
Novelty: 0.05571844
Score: 0.548
Data Source: STRINGDB
GANC
Tchem
Family: Enzyme
Novelty: 0.02123234
Score: 0.536
Data Source: STRINGDB
NXPH4
Tbio
Novelty: 0.09172552
Score: 0.511
Data Source: STRINGDB
AGO2
Tbio
Novelty: 0.00057003
Score: 0.499
Data Source: STRINGDB
Publication Statistics
PubMed Score  127.95

PubMed score by year
PubTator Score  9.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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