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Tbio
PAQR5
Membrane progestin receptor gamma

Protein Summary
Description
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (PubMed:12601167).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340965
  • ENSP00000343877
  • ENSG00000137819
  • ENST00000395407
  • ENSP00000378803
  • ENST00000561153
  • ENSP00000453526

Symbol
  • MPRG
  • MPRG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
tissue sample
0.67
histone modification site profile
0.63
phenotype
0.63
microRNA
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.59   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.59   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (46)
1 – 10 of 46
PHYHIP
Tdark
Family:  Enzyme
Novelty:  0.25773185
p_int:  0.987254947
p_ni:  0.012653197
p_wrong:  0.000091856
Score:  0.622
Data Source:  BioPlex,STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.911
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.908
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.907
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.907
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.907
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.907
Data Source:  STRINGDB
GNGT1
Tbio
Novelty:  0.05291961
Score:  0.9
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.9
Data Source:  STRINGDB
PRELID2
Tdark
Novelty:  0.38276284
Score:  0.67
Data Source:  STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
78.3
basophil count
2
2
2
67.5
basophil percentage of leukocytes
1
1
1
59
lymphocyte count
1
1
1
44.2
calcium measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
78.3
basophil count
2
67.5
basophil percentage of leukocytes
1
59
lymphocyte count
1
44.2
calcium measurement
1
30.2
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progestin and adipoQ receptor family member 5
VGNC:1900
748538
Macaque
progestin and adipoQ receptor family member 5
695109
Mouse
MGI:1921340
74090
Rat
RGD:1311259
315741
Dog
progestin and adipoQ receptor family member 5
VGNC:44261
487623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progestin and adipoQ receptor family member 5
Macaque
progestin and adipoQ receptor family member 5
Mouse
Rat
Dog
progestin and adipoQ receptor family member 5
Publication Statistics
PubMed Score 16.59
PubMed score by year
PubTator Score 2.31
PubTator score by year