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Tbio
TRMT1
tRNA (guanine(26)-N(2))-dimethyltransferase

Protein Summary
Description
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221504
  • ENSP00000221504
  • ENSG00000104907
  • ENST00000357720
  • ENSP00000350352
  • ENST00000437766
  • ENSP00000416149
  • ENST00000592062
  • ENSP00000466967

Symbol
  • TRM1
  • MRT68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
molecular function
0.76
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.59   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.59   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (251)
PUF60
Tbio
Novelty:  0.02667356
p_int:  0.999935242
p_ni:  0.000064758
Score:  0.176
Data Source:  BioPlex,STRINGDB
RNASE10
Tdark
Family:  Enzyme
Novelty:  0.1032541
p_int:  0.999879023
p_ni:  0.000120956
p_wrong:  2.1e-8
Data Source:  BioPlex
CHDH
Tbio
Family:  Enzyme
Novelty:  0.02147468
p_int:  0.999553207
p_ni:  0.0004081
p_wrong:  0.000038692
Score:  0.561
Data Source:  BioPlex,STRINGDB
HEMK1
Tbio
Family:  Enzyme
Novelty:  0.03509926
p_int:  0.996827961
p_ni:  0.00025003
p_wrong:  0.002922008
Score:  0.323
Data Source:  BioPlex,STRINGDB
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.996657803
p_ni:  0.003342197
Score:  0.209
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.996398513
p_ni:  0.003364155
p_wrong:  0.000237333
Data Source:  BioPlex
LIPG
Tchem
Family:  Enzyme
Novelty:  0.00412129
p_int:  0.994320036
p_ni:  0.005679964
Score:  0.19
Data Source:  BioPlex,STRINGDB
PDP1
Tbio
Family:  Enzyme
Novelty:  0.00442352
p_int:  0.99421004
p_ni:  0.00578996
Data Source:  BioPlex
RSAD1
Tdark
Novelty:  0.63344405
p_int:  0.991438989
p_ni:  0.008561011
Score:  0.194
Data Source:  BioPlex,STRINGDB
PDPR
Tbio
Family:  Enzyme
Novelty:  0.04223174
p_int:  0.989516753
p_ni:  0.010483247
Score:  0.244
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
4
4
88.4
monocyte count
2
2
2
86.8
platelet crit
1
2
2
77.6
mean platelet volume
2
2
2
76.2
self reported educational attainment
3
3
3
5.9
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
88.4
monocyte count
2
86.8
platelet crit
2
77.6
mean platelet volume
2
76.2
self reported educational attainment
3
5.9
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 1
VGNC:2213
455758
Macaque
tRNA methyltransferase 1
718227
Mouse
MGI:1289155
212528
Rat
RGD:1305992
288914
Dog
tRNA methyltransferase 1
VGNC:47850
476692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 1
Macaque
tRNA methyltransferase 1
Mouse
Rat
Dog
tRNA methyltransferase 1
Publication Statistics
PubMed Score 55.59
PubMed score by year
PubTator Score 5.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title