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Tdark
TOR4A
Torsin-4A

Protein Classes
Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357503
  • ENSP00000350102
  • ENSG00000198113

Symbol
  • C9orf167
  • C9orf167
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
molecular function
0.73
transcription factor binding site profile
0.71
cell type or tissue
0.64
tissue sample
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.34   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
2
3
1.1
90.8
glomerular filtration rate
3
3
4
89.1
creatinine measurement
1
2
2
86.1
mathematical ability
4
2
4
85.2
reticulocyte measurement
3
1
3
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
3
1.1
90.8
glomerular filtration rate
4
89.1
creatinine measurement
2
86.1
mathematical ability
4
85.2
reticulocyte measurement
3
82.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
torsin family 4 member A
704865
Mouse
MGI:2442720
227612
Rat
RGD:1308019
311795
Dog
torsin family 4 member A
VGNC:47716
491229
Horse
torsin family 4 member A [Source:HGNC Symbol;Acc:HGNC:25981]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
torsin family 4 member A
Mouse
Rat
Dog
torsin family 4 member A
Horse
torsin family 4 member A [Source:HGNC Symbol;Acc:HGNC:25981]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NXH8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (78)
1 – 10 of 78
QSOX1
Tbio
Family:  Enzyme
Novelty:  0.02152583
Score:  0.908
Data Source:  STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.908
Data Source:  STRINGDB
FERMT3
Tbio
Novelty:  0.01172918
Score:  0.905
Data Source:  STRINGDB
CFD
Tchem
Family:  Enzyme
Novelty:  0.00326222
Score:  0.905
Data Source:  STRINGDB
TIMP1
Tbio
Family:  Enzyme
Novelty:  0.00020986
Score:  0.904
Data Source:  STRINGDB
SRGN
Tbio
Novelty:  0.00570752
Score:  0.904
Data Source:  STRINGDB
SERPINF2
Tbio
Novelty:  0.00054719
Score:  0.904
Data Source:  STRINGDB
THBS1
Tchem
Novelty:  0.00073905
Score:  0.903
Data Source:  STRINGDB
SERPINE1
Tchem
Novelty:  0.00017629
Score:  0.903
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.34

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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