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Tdark
THUMPD1
THUMP domain-containing protein 1

Protein Summary
Description
Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation (PubMed:25653167).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381337
  • ENSP00000370741
  • ENSG00000066654
  • ENST00000396083
  • ENSP00000379392
  • ENST00000636554
  • ENSP00000490841

Symbol
  • Tan1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.84
transcription factor binding site profile
0.79
transcription factor perturbation
0.74
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
45.2
glomerular filtration rate
1
1
1
37.6
creatinine measurement
1
1
1
37.6
urate measurement
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
45.2
glomerular filtration rate
1
37.6
creatinine measurement
1
37.6
urate measurement
1
36.9
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
THUMP domain containing 1
VGNC:5935
453976
Macaque
THUMP domain containing 1
696746
Mouse
MGI:2444479
233802
Rat
Dog
THUMP domain containing 1
VGNC:47360
489984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
THUMP domain containing 1
Macaque
THUMP domain containing 1
Mouse
Rat
Dog
THUMP domain containing 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NXG2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (55)
1 – 10 of 55
PUS7
Tbio
Family:  Enzyme
Novelty:  0.04867669
p_int:  0.99999992
p_ni:  7.7e-8
p_wrong:  3e-9
Score:  0.717
Data Source:  BioPlex,STRINGDB
QTRT1
Tbio
Family:  Enzyme
Novelty:  0.04387363
p_int:  0.999998026
p_ni:  0.000001918
p_wrong:  5.6e-8
Score:  0.27
Data Source:  BioPlex,STRINGDB
FDXACB1
Tdark
Novelty:  67
p_int:  0.999962446
p_ni:  0.000022334
p_wrong:  0.00001522
Score:  0.579
Data Source:  BioPlex,STRINGDB
ZC3H8
Tbio
Novelty:  0.41677629
p_int:  0.999471298
p_ni:  0.000528702
Score:  0.188
Data Source:  BioPlex,STRINGDB
NAT10
Tbio
Family:  Enzyme
Novelty:  0.02453679
p_int:  0.998925479
p_ni:  0.001074521
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
PUS1
Tbio
Family:  Enzyme
Novelty:  0.01923618
p_int:  0.998655509
p_ni:  0.001344491
Score:  0.366
Data Source:  BioPlex,STRINGDB
CCL26
Tbio
Novelty:  0.00556498
p_int:  0.997825087
p_ni:  0.001989666
p_wrong:  0.000185247
Data Source:  BioPlex
LUM
Tbio
Novelty:  0.00219939
p_int:  0.915294509
p_ni:  0.081907702
p_wrong:  0.002797789
Score:  0.237
Data Source:  BioPlex,STRINGDB
TAS2R41
Tchem
Family:  GPCR
Novelty:  0.56248837
p_int:  0.80520028
p_ni:  0.014481014
p_wrong:  0.180318707
Score:  0.165
Data Source:  BioPlex,STRINGDB
YBX1
Tbio
Family:  TF
Novelty:  0.00132108
p_int:  0.76503938
p_ni:  0.23496062
Score:  0.182
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.92

PubMed score by year
PubTator Score  1.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer