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Tbio
ZDHHC7
Palmitoyltransferase ZDHHC7

Protein Summary
Description
Palmitoyltransferase with broad specificity (PubMed:22031296, PubMed:28196865). Palmitoylates JAM3 (PubMed:28196865). Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313732
  • ENSP00000315604
  • ENSG00000153786
  • ENST00000344861
  • ENSP00000341681
  • ENST00000564466
  • ENSP00000456782

Symbol
  • DHHC7
  • SERZ1
  • SERZ-B
  • ZNF370
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
kinase perturbation
0.88
histone modification site profile
0.81
transcription factor binding site profile
0.78
cell type or tissue
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.74   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.74   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
17.8
body height
1
1
1
6.2
BMI-adjusted waist circumference
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
17.8
body height
1
6.2
BMI-adjusted waist circumference
1
4.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 7
VGNC:9205
454390
Macaque
zinc finger DHHC-type containing 7
718634
Mouse
MGI:2142662
102193
Rat
RGD:620205
170906
Dog
zinc finger DHHC-type containing 7
VGNC:48593
489676
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 7
Macaque
zinc finger DHHC-type containing 7
Mouse
Rat
Dog
zinc finger DHHC-type containing 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NXF8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Extra-nuclear estrogen signaling
Signal Transduction
Signaling by Nuclear Receptors
Protein-Protein Interactions (24)
1 – 10 of 24
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
p_int:  0.999969068
p_ni:  0.00003092
p_wrong:  1.1e-8
Score:  0.219
Data Source:  BioPlex,STRINGDB
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.996900902
p_ni:  1.01e-7
p_wrong:  0.003098997
Data Source:  BioPlex
MARCH6
Tbio
Family:  Enzyme
Novelty:  0.01818691
p_int:  0.992353542
p_ni:  0.000138148
p_wrong:  0.00750831
Score:  0.324
Data Source:  BioPlex,STRINGDB
TMEM186
Tdark
Novelty:  0.59951294
p_int:  0.947196019
p_ni:  0.052803981
Score:  0.214
Data Source:  BioPlex,STRINGDB
NDFIP1
Tbio
Novelty:  0.04496467
p_int:  0.763166908
p_ni:  0.236832657
p_wrong:  4.34e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CYB5B
Tbio
Novelty:  0.09395308
Score:  0.665
Data Source:  STRINGDB
ABHD13
Tdark
Family:  Enzyme
Novelty:  2.01646617
Score:  0.601
Data Source:  STRINGDB
SDR42E1
Tdark
Family:  Enzyme
Novelty:  2.41213299
Score:  0.594
Data Source:  STRINGDB
GOLGA7
Tbio
Novelty:  0.17108842
Score:  0.573
Data Source:  STRINGDB
PBX2
Tbio
Family:  TF
Novelty:  0.01339291
Score:  0.565
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.74

PubMed score by year
PubTator Score  9.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer