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Tdark
CWC25
Pre-mRNA-splicing factor CWC25 homolog

Protein Summary
Description
This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000614790
  • ENSP00000478070
  • ENSG00000273559
  • ENST00000614868
  • ENSP00000477799
  • ENSG00000276761

Symbol
  • CCDC49
  • CCDC49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.9
transcription factor
0.67
transcription factor binding site profile
0.67
cell line
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.99   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.99   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
19.4
intraocular pressure measurement
1
1
1
19.4
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
19.4
intraocular pressure measurement
1
19.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CWC25 spliceosome associated protein homolog
VGNC:14180
454617
Macaque
CWC25 spliceosome associated protein homolog
695474
Mouse
MGI:1914730
67480
Rat
RGD:1305258
360613
Dog
CWC25 spliceosome associated protein homolog
VGNC:39742
480536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CWC25 spliceosome associated protein homolog
Macaque
CWC25 spliceosome associated protein homolog
Mouse
Rat
Dog
CWC25 spliceosome associated protein homolog
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NXE8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (261)
1 – 10 of 261
CYTH4
Tbio
Novelty: 0.05783135
p_int: 0.999999095
p_ni: 5e-9
p_wrong: 9e-7
Data Source: BioPlex
DHX38
Tbio
Family: Enzyme
Novelty: 0.01939445
Score: 0.998
Data Source: STRINGDB
CDC40
Tbio
Novelty: 0.03139044
Score: 0.995
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.995
Data Source: STRINGDB
CWC22
Tbio
Novelty: 0.027689
Score: 0.994
Data Source: STRINGDB
EFTUD2
Tbio
Novelty: 0.01805571
Score: 0.994
Data Source: STRINGDB
SNRNP200
Tbio
Family: Enzyme
Novelty: 0.01339666
Score: 0.992
Data Source: STRINGDB
CWC15
Tbio
Novelty: 0.00205068
Score: 0.992
Data Source: STRINGDB
XAB2
Tbio
Novelty: 0.04104647
Score: 0.992
Data Source: STRINGDB
SNRPA1
Tbio
Novelty: 0.01232044
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.99

PubMed score by year
PubTator Score  1.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer