You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SMPD4
Sphingomyelin phosphodiesterase 4

Protein Summary
Description
Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351288
  • ENSP00000259217
  • ENSG00000136699
  • ENST00000409031
  • ENSP00000386531
  • ENST00000431183
  • ENSP00000405187

Symbol
  • KIAA1418
  • SKNY
  • SKNY
  • NET13
  • NSMASE3
  • NSMASE-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
virus perturbation
0.79
transcription factor binding site profile
0.77
cellular component
0.71
tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.911014532
p_ni:  0.088985468
Data Source:  BioPlex
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.909056446
p_ni:  0.090943554
Data Source:  BioPlex
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
p_int:  0.902771274
p_ni:  0.097228726
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.831938095
p_ni:  0.168061905
Data Source:  BioPlex
SGMS1
Tchem
Family:  Enzyme
Novelty:  0.01717229
Score:  0.962
Data Source:  STRINGDB
SMPD3
Tchem
Family:  Enzyme
Novelty:  0.01053328
Score:  0.959
Data Source:  STRINGDB
SGMS2
Tchem
Family:  Enzyme
Novelty:  0.01360669
Score:  0.958
Data Source:  STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
Score:  0.956
Data Source:  STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
Score:  0.949
Data Source:  STRINGDB
CERK
Tchem
Family:  Kinase
Novelty:  0.0103948
Score:  0.946
Data Source:  STRINGDB
Pathways (7)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sphingomyelin phosphodiesterase 4
718018
Mouse
MGI:1924876
77626
Rat
RGD:1310674
303790
Dog
sphingomyelin phosphodiesterase 4
VGNC:46572
486434
Horse
sphingomyelin phosphodiesterase 4
VGNC:23356
100052086
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sphingomyelin phosphodiesterase 4
Mouse
Rat
Dog
sphingomyelin phosphodiesterase 4
Horse
sphingomyelin phosphodiesterase 4
Publication Statistics
PubMed Score 13.47
PubMed score by year
PubTator Score 3.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title