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Tdark
MIOS
GATOR complex protein MIOS

Protein Summary
Description
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340080
  • ENSP00000339881
  • ENSG00000164654
  • ENST00000405785
  • ENSP00000384088

Symbol
  • MIO
  • Sea4
  • Yulink
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.84
cell type or tissue
0.75
histone modification site profile
0.72
cell line
0.59


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
meiosis regulator for oocyte development
VGNC:10499
472289
Macaque
meiosis regulator for oocyte development
696371
Mouse
MGI:2182066
252875
Rat
RGD:1308432
362324
Dog
meiosis regulator for oocyte development
VGNC:43239
482316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
meiosis regulator for oocyte development
Macaque
meiosis regulator for oocyte development
Mouse
Rat
Dog
meiosis regulator for oocyte development
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NXC5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
SGD
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (62)
1 – 10 of 62
RFPL4B
Tdark
Novelty:  2.42779597
p_int:  0.999997559
p_ni:  0.000002441
Data Source:  BioPlex
SEC13
Tbio
Novelty:  0.00709413
p_int:  0.999996345
p_ni:  0.000003655
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999979394
p_ni:  0.000020606
Data Source:  BioPlex
CASTOR1
Tbio
Novelty:  0.10145237
p_int:  0.999978292
p_ni:  0.000021698
p_wrong:  1e-8
Score:  0.721
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.996884574
p_ni:  0.003114873
p_wrong:  5.53e-7
Data Source:  BioPlex
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.992584564
p_ni:  0.007415436
Data Source:  BioPlex
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.991794941
p_ni:  0.008203645
p_wrong:  0.000001414
Data Source:  BioPlex
DOK3
Tbio
Novelty:  0.06212348
p_int:  0.990980059
p_ni:  0.009019941
Score:  0.204
Data Source:  BioPlex,STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.973528688
p_ni:  0.026363151
p_wrong:  0.000108161
Data Source:  BioPlex
RFPL2
Tdark
Novelty:  1.87914964
p_int:  0.962420077
p_ni:  0.037543918
p_wrong:  0.000036006
Score:  0.181
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.02

PubMed score by year
PubTator Score  15.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer