Tchem SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial

Protein Summary

Description

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9NXA8
• B4DFM4
• B4DYJ5
• F5H5Z9
• Q5T294
• Q5T295
• Q9Y6E6

Gene Name

• SIRT5

Ensembl ID

• ENST00000359782
• ENSP00000352830
• ENSG00000124523
• ENST00000379262
• ENSP00000368564
• ENST00000397350
• ENSP00000380509
• ENST00000606117
• ENSP00000476228

Symbol

• SIR2L5
• SIR2L5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
molecular function	0.88
histone modification site profile	0.82
disease perturbation	0.79
transcription factor binding site profile	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Nad-dependent Protein Deacylase Sirtuin-5, Mitochondrial

Protein / Hydrolase / Deacetylase / Nad-dependent Protein Deacylase Sirtuin-5, Mitochondrial

DTO Classes

Protein / Epigenetic Regulator / Eraser / Histone Deacetylase / Hdac Class Iii / Nad-dependent Protein Deacylase Sirtuin-5, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.59   (req: < 5)

Gene RIFs: 82   (req: <= 3)

Antibodies: 581   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.59   (req: >= 5)

Gene RIFs: 82   (req: > 3)

Antibodies: 581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1