Tbio SYBU Syntabulin

Protein Summary

Description

Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 17611281]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NX95
• A8K354
• B3KQX3
• B3KU61
• Q5R1T1
• Q5R1T2
• Q5R1T3
• Q5Y2M6
• Q8ND49
• Q8TCR6
• Q96D80
• Q9P256

Gene Name

• SYBU

Ensembl ID

• ENST00000276646
• ENSP00000276646
• ENSG00000147642
• ENST00000399066
• ENSP00000382019
• ENST00000408889
• ENSP00000386196
• ENST00000408908
• ENSP00000386154
• ENST00000422135
• ENSP00000407118
• ENST00000433638
• ENSP00000403544
• ENST00000440310
• ENSP00000404369
• ENST00000446070
• ENSP00000414748
• ENST00000528331
• ENSP00000436041
• ENST00000528647
• ENSP00000432501
• ENST00000532779
• ENSP00000436266
• ENST00000533065
• ENSP00000432962
• ENST00000533171
• ENSP00000434679
• ENST00000533895
• ENSP00000433446

Symbol

• GOLSYN
• KIAA1472
• OCSYN
• SNPHL
• GOLSYN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.76
small molecule perturbation	0.76
tissue sample	0.68
virus perturbation	0.64
histone modification site profile	0.52

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntabulin

Protein / Enzyme Modulator / Syntabulin

DTO Classes

Protein / Transporter / Snare Protein / Syntabulin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.95   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 15   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.95   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0