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Tbio
CMTM6
CKLF-like MARVEL transmembrane domain-containing protein 6

Protein Summary
Description
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205636
  • ENSP00000205636
  • ENSG00000091317

Symbol
  • CKLFSF6
  • CKLFSF6
  • PRO2219
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.88
virus perturbation
0.83
disease perturbation
0.79
microRNA
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
4
4
85.3
total cholesterol measurement
3
2
3
78
apolipoprotein B measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
85.3
total cholesterol measurement
3
78
apolipoprotein B measurement
1
52.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CKLF like MARVEL transmembrane domain containing 6
VGNC:11374
746602
Macaque
CKLF like MARVEL transmembrane domain containing 6
704441
Mouse
MGI:2447165
67213
Rat
RGD:1307765
316035
Dog
CKLF like MARVEL transmembrane domain containing 6
VGNC:39383
609718
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CKLF like MARVEL transmembrane domain containing 6
Macaque
CKLF like MARVEL transmembrane domain containing 6
Mouse
Rat
Dog
CKLF like MARVEL transmembrane domain containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NX76-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (164)
1 – 10 of 164
PMEL
Tbio
Novelty: 0.00116525
p_int: 0.804236488
p_ni: 0.195762385
p_wrong: 0.000001126
Score: 0.23
Data Source: BioPlex,STRINGDB
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.79549951
p_ni: 0.197682173
p_wrong: 0.006818317
Data Source: BioPlex
ATP6V0C
Tbio
Family: Enzyme
Novelty: 0.01142874
Score: 0.939
Data Source: STRINGDB
CMTM8
Tbio
Novelty: 0.0953768
Score: 0.928
Data Source: STRINGDB
GLIPR1
Tbio
Novelty: 0.03474569
Score: 0.924
Data Source: STRINGDB
LAMP2
Tbio
Novelty: 0.00168009
Score: 0.911
Data Source: STRINGDB
LAMTOR2
Tbio
Novelty: 0.05210182
Score: 0.909
Data Source: STRINGDB
VAMP8
Tbio
Novelty: 0.01083228
Score: 0.909
Data Source: STRINGDB
DDOST
Tchem
Family: Enzyme
Novelty: 0.01797594
Score: 0.909
Data Source: STRINGDB
LAMTOR3
Tbio
Novelty: 0.050644
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.73

PubMed score by year
PubTator Score  3.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer