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Tbio
DUS2
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

Protein Summary
Description
Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358896
  • ENSP00000351769
  • ENSG00000167264
  • ENST00000565263
  • ENSP00000455229

Symbol
  • DUS2L
  • SMM1
  • DUS2L
  • URLC8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
molecular function
0.88
transcription factor binding site profile
0.84
cell type or tissue
0.72
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
51.2
eosinophil count
1
1
1
27.7
low density lipoprotein cholesterol measurement
1
1
1
25.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
51.2
eosinophil count
1
27.7
low density lipoprotein cholesterol measurement
1
25.3
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Protein-Protein Interactions (71)
1 – 10 of 71
KANSL1
Tbio
Novelty: 0.03032662
p_int: 0.999995416
p_ni: 0.000004452
p_wrong: 1.31e-7
Score: 0.369
Data Source: BioPlex,STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.998
Data Source: Reactome,STRINGDB
TRMT1
Tbio
Family: Enzyme
Novelty: 0.01795504
Score: 0.862
Data Source: STRINGDB
TRMT5
Tbio
Family: Enzyme
Novelty: 0.02509765
Score: 0.792
Data Source: STRINGDB
TRIT1
Tbio
Family: Enzyme
Novelty: 0.00296723
Score: 0.768
Data Source: STRINGDB
TRMT61A
Tbio
Family: Enzyme
Novelty: 0.04443394
Score: 0.742
Data Source: STRINGDB
DDX28
Tbio
Family: Enzyme
Novelty: 0.16760542
Score: 0.708
Data Source: STRINGDB
STRBP
Tbio
Novelty: 0.00919158
Score: 0.704
Data Source: STRINGDB
PCDHA5
Tdark
Novelty: 0.9863324
Score: 0.678
Data Source: STRINGDB
TARBP1
Tbio
Family: Enzyme
Novelty: 0.04886897
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.39

PubMed score by year
PubTator Score  10.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer