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Tbio
MED29
Mediator of RNA polymerase II transcription subunit 29

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000594368
  • ENSP00000472501
  • ENSG00000063322
  • ENST00000599213
  • ENSP00000471802

Symbol
  • IXL
  • IXL
  • MED2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
histone modification site profile
0.83
transcription factor binding site profile
0.81
transcription factor
0.79
microRNA
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999993451
p_ni:  0.000006548
Score:  0.996
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999991675
p_ni:  0.000008325
Score:  0.996
Data Source:  BioPlex,STRINGDB
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.999991168
p_ni:  0.000008832
Score:  0.997
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999983473
p_ni:  0.000016527
Data Source:  BioPlex
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.999982787
p_ni:  0.000017213
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999901268
p_ni:  0.000098732
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED28
Tbio
Family:  Enzyme
Novelty:  0.00362108
p_int:  0.999897243
p_ni:  0.000102757
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.999821652
p_ni:  0.000178348
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCNC
Tbio
Novelty:  0.00585842
p_int:  0.999602933
p_ni:  0.000397067
Score:  0.989
Data Source:  BioPlex,STRINGDB
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.999587127
p_ni:  0.000412861
p_wrong:  1.2e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
77
myeloid white cell count
1
1
1
62.5
leukocyte count
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
77
myeloid white cell count
1
62.5
leukocyte count
1
55.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 29
VGNC:11181
736237
Macaque
mediator complex subunit 29
698032
Mouse
MGI:1914474
67224
Rat
RGD:1311009
292751
Dog
mediator complex subunit 29
VGNC:43136
612535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 29
Macaque
mediator complex subunit 29
Mouse
Rat
Dog
mediator complex subunit 29
Publication Statistics
PubMed Score 54.85
PubMed score by year
PubTator Score 125.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title