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Tbio
CHCHD3
MICOS complex subunit MIC19

Protein Summary
Description
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180). The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262570
  • ENSP00000262570
  • ENSG00000106554

Symbol
  • MIC19
  • MINOS3
  • Mic19
  • MINOS3
  • MICOS19
  • PPP1R22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
interacting protein
0.92
transcription factor perturbation
0.88
transcription factor binding site profile
0.8
cell type or tissue
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.13   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
81.8
smoking status measurement
2
2
2
79.5
cognitive function measurement
1
1
1
68.5
insomnia measurement
1
1
0
1
63.4
smoking initiation
1
1
1
62.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
81.8
smoking status measurement
2
79.5
cognitive function measurement
1
68.5
insomnia measurement
0
1
63.4
smoking initiation
1
62.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain containing 3
VGNC:4305
463739
Macaque
coiled-coil-helix-coiled-coil-helix domain containing 3
705217
Mouse
MGI:1913325
66075
Rat
RGD:1310325
296966
Dog
coiled-coil-helix-coiled-coil-helix domain containing 3
VGNC:39195
607574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain containing 3
Macaque
coiled-coil-helix-coiled-coil-helix domain containing 3
Mouse
Rat
Dog
coiled-coil-helix-coiled-coil-helix domain containing 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NX63-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial protein import
Reactome
Organelle biogenesis and maintenance
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Mitochondrial protein import
Organelle biogenesis and maintenance
Protein localization
Protein-Protein Interactions (96)
1 – 10 of 96
MTX2
Tbio
Novelty: 0.02047483
p_int: 0.984710353
p_ni: 0.015289647
Score: 0.994
Data Source: BioPlex,STRINGDB
TRAK1
Tbio
Novelty: 0.03561577
p_int: 0.93335493
p_ni: 0.06664507
Data Source: BioPlex
IMMT
Tbio
Novelty: 0.00260309
Score: 0.996
Data Source: STRINGDB
SAMM50
Tbio
Novelty: 0.00553631
Score: 0.995
Data Source: STRINGDB
APOOL
Tbio
Novelty: 0.08233023
Score: 0.982
Data Source: STRINGDB
MINOS1
Tdark
Novelty: 0.40437095
Score: 0.982
Data Source: STRINGDB
APOO
Tbio
Novelty: 0.04964756
Score: 0.979
Data Source: STRINGDB
DNAJC11
Tbio
Novelty: 0.31080011
Score: 0.978
Data Source: STRINGDB
MTX1
Tbio
Novelty: 0.02350764
Score: 0.973
Data Source: STRINGDB
MIC13
Tbio
Novelty: 0.03686888
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.13

PubMed score by year
PubTator Score  8.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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