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Tdark
TMEM161A
Transmembrane protein 161A

Protein Summary
Description
May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000162044
  • ENSP00000162044
  • ENSG00000064545
  • ENST00000450333
  • ENSP00000404208

Symbol
  • AROS-29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
kinase perturbation
0.76
tissue sample
0.67
gene perturbation
0.59
biological process
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.15   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.15   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipid measurement
1
1
1
35.3
blood metabolite measurement
1
1
1
35.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipid measurement
1
35.3
blood metabolite measurement
1
35.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 161A
VGNC:2223
455869
Macaque
transmembrane protein 161A
720329
Mouse
MGI:2384577
234371
Rat
RGD:1307703
364535
Dog
transmembrane protein 161A
VGNC:47489
484810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 161A
Macaque
transmembrane protein 161A
Mouse
Rat
Dog
transmembrane protein 161A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NX61-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (28)
1 – 10 of 28
SLC25A42
Tbio
Family: Transporter
Novelty: 0.15737382
Score: 0.794
Data Source: STRINGDB
CASKIN2
Tdark
Novelty: 0.43801968
Score: 0.777
Data Source: STRINGDB
TMEM94
Tdark
Novelty: 0.39746809
Score: 0.775
Data Source: STRINGDB
C11orf1
Tdark
Novelty: 1.59731466
Score: 0.7
Data Source: STRINGDB
POPDC2
Tbio
Novelty: 0.13553064
Score: 0.659
Data Source: STRINGDB
MANEAL
Tdark
Family: Enzyme
Novelty: 0.71535497
Score: 0.597
Data Source: STRINGDB
KLHL31
Tbio
Novelty: 0.10153296
Score: 0.551
Data Source: STRINGDB
DPT
Tbio
Novelty: 0.01984221
Score: 0.512
Data Source: STRINGDB
TMEM38A
Tbio
Family: IC
Novelty: 0.10891929
Score: 0.51
Data Source: STRINGDB
CHST7
Tbio
Family: Enzyme
Novelty: 0.18769086
Score: 0.497
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.15

PubMed score by year
PubTator Score  1.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer