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Tbio
LYAR
Cell growth-regulating nucleolar protein

Protein Summary
Description
Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227). Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918). In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580). Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918). Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells (By similarity). Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343470
  • ENSP00000345917
  • ENSG00000145220
  • ENST00000452476
  • ENSP00000397367

Symbol
  • ZLYAR
  • ZC2HC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
histone modification site profile
0.88
kinase perturbation
0.88
cell type or tissue
0.78
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.87   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.87   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (226)
1 – 10 of 226
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.869096303
p_ni: 0.130903697
Score: 0.234
Data Source: BioPlex,STRINGDB
MAGEB10
Tdark
Novelty: 2.96156972
p_int: 0.843833593
p_ni: 0.156166407
Score: 0.173
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.788867131
p_ni: 0.211132869
Score: 0.266
Data Source: BioPlex,STRINGDB
BRIX1
Tbio
Novelty: 0.16561444
Score: 0.948
Data Source: STRINGDB
ESF1
Tbio
Novelty: 0.03295863
Score: 0.938
Data Source: STRINGDB
NOP14
Tbio
Novelty: 0.08903014
Score: 0.93
Data Source: STRINGDB
KRI1
Tdark
Novelty: 0.25087604
Score: 0.929
Data Source: STRINGDB
DDX55
Tdark
Family: Enzyme
Novelty: 0.27887497
Score: 0.926
Data Source: STRINGDB
RRS1
Tbio
Novelty: 0.01643671
Score: 0.9
Data Source: STRINGDB
EBNA1BP2
Tbio
Novelty: 0.02083466
Score: 0.898
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.87

PubMed score by year
PubTator Score  6.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer