Tbio HYPK Huntingtin-interacting protein K

Protein Summary

Description

Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.

Uniprot Accession IDs

• Q9NX55
• C9JKJ0
• O75408
• Q8WUW8
• Q9P024

Gene Name

• HYPK

Ensembl ID

• ENST00000406925
• ENSP00000384474
• ENSG00000242028
• ENST00000442995
• ENSP00000401155

Symbol

• C15orf63
• HSPC136
• C15orf63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.86
kinase perturbation	0.81
tissue sample	0.81
disease perturbation	0.79
cell type or tissue	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.88   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 6   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.88   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0