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Tbio
MARCH5
E3 ubiquitin-protein ligase MARCH5

Protein Summary
Description
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358935
  • ENSP00000351813
  • ENSG00000198060

Symbol
  • RNF153
  • MITOL
  • RNF153
  • MARCH-V
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.96
virus perturbation
0.95
histone modification site profile
0.85
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.81   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.81   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
71.6
monocyte percentage of leukocytes
1
1
1
36.5
BMI-adjusted waist-hip ratio
1
1
1
30.2
waist-hip ratio
1
1
1
12.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
71.6
monocyte percentage of leukocytes
1
36.5
BMI-adjusted waist-hip ratio
1
30.2
waist-hip ratio
1
12.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 5
VGNC:9748
450607
Macaque
membrane associated ring-CH-type finger 5
698517
Mouse
MGI:1915207
69104
Rat
RGD:1305617
294079
Dog
membrane associated ring-CH-type finger 5
VGNC:43018
612766
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 5
Macaque
membrane associated ring-CH-type finger 5
Mouse
Rat
Dog
membrane associated ring-CH-type finger 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NX47-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (67)
1 – 10 of 67
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.999998858
p_ni:  9.1e-7
p_wrong:  2.33e-7
Data Source:  BioPlex
OR12D3
Tdark
Family:  oGPCR
Novelty:  2.8827767
p_int:  0.999994759
p_ni:  0.000004929
p_wrong:  3.12e-7
Data Source:  BioPlex
MFN2
Tbio
Novelty:  0.00137876
p_int:  0.999634738
p_ni:  0.00036522
p_wrong:  4.1e-8
Score:  0.916
Data Source:  BioPlex,STRINGDB
GRAMD2B
Tdark
Novelty:  0.55744753
p_int:  0.988219899
p_ni:  3.6e-7
p_wrong:  0.011779741
Score:  0.243
Data Source:  BioPlex,STRINGDB
MIA3
Tbio
Novelty:  0.02784348
p_int:  0.912228903
p_ni:  0.087771097
Score:  0.209
Data Source:  BioPlex,STRINGDB
MFN1
Tbio
Novelty:  0.00372574
Score:  0.853
Data Source:  STRINGDB
UBE2E1
Tbio
Novelty:  0.04048768
Score:  0.8
Data Source:  STRINGDB
FIS1
Tbio
Novelty:  0.0033607
Score:  0.786
Data Source:  STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.775
Data Source:  STRINGDB
FUNDC1
Tbio
Novelty:  0.02333176
Score:  0.775
Data Source:  STRINGDB
Publication Statistics
PubMed Score  47.81

PubMed score by year
PubTator Score  109.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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