You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADPRHL2
Poly(ADP-ribose) glycohydrolase ARH3

Protein Summary
Description
Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373178
  • ENSP00000362273
  • ENSG00000116863

Symbol
  • ARH3
  • ARH3
  • CONDSIAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor binding site profile
0.79
tissue sample
0.71
histone modification site profile
0.57
transcription factor
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.57   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.57   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP-ribosylhydrolase like 2
VGNC:41
456750
Mouse
MGI:2140364
100206
Rat
RGD:1309068
362600
Dog
ADP-ribosylhydrolase like 2
VGNC:54191
608601
Horse
ADP-ribosylhydrolase like 2
VGNC:15129
100069360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP-ribosylhydrolase like 2
Mouse
Rat
Dog
ADP-ribosylhydrolase like 2
Horse
ADP-ribosylhydrolase like 2
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
DNA Repair
Reactome
POLB-Dependent Long Patch Base Excision Repair
Reactome
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Reactome
Resolution of Abasic Sites (AP sites)
Name
Explore in Pharos
Explore in Source
Base Excision Repair
DNA Repair
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of Abasic Sites (AP sites)
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (59)
1 – 10 of 59
RAD54L2
Tdark
Family: Enzyme
Novelty: 0.26668341
p_int: 0.998325612
p_ni: 0.001674388
p_wrong: 1e-9
Data Source: BioPlex
PARG
Tchem
Family: Enzyme
Novelty: 0.00424731
Score: 0.901
Data Source: STRINGDB
MACROD2
Tbio
Family: Enzyme
Novelty: 0.02685751
Score: 0.892
Data Source: STRINGDB
PCID2
Tbio
Novelty: 0.22455574
Score: 0.862
Data Source: STRINGDB
MACROD1
Tbio
Family: Enzyme
Novelty: 0.03610474
Score: 0.828
Data Source: STRINGDB
OARD1
Tdark
Family: Enzyme
Novelty: 0.14445866
Score: 0.769
Data Source: STRINGDB
TNKS
Tchem
Family: Enzyme
Novelty: 0.00404545
Score: 0.699
Data Source: STRINGDB
TROVE2
Tbio
Novelty: 0.00306038
Score: 0.678
Data Source: STRINGDB
PARP1
Tclin
Family: Enzyme
Novelty: 0.00033016
Score: 0.658
Data Source: STRINGDB
PARP3
Tclin
Family: Enzyme
Novelty: 0.01712237
Score: 0.655
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.57

PubMed score by year
PubTator Score  21.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer