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Tbio
DNAJC28
DnaJ homolog subfamily C member 28

Protein Summary
Description
May have a role in protein folding or as a chaperone. This gene encodes a member of the DnaJ heat shock protein family. The encoded protein, which contains a conserved N-terminal DnaJ domain, is thought to play a role in protein folding or act as a molecular chaperone protein. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314399
  • ENSP00000320303
  • ENSG00000177692
  • ENST00000381947
  • ENSP00000371373
  • ENST00000402202
  • ENSP00000385777
  • ENST00000571432
  • ENSP00000461665
  • ENSG00000262911
  • ENST00000572540
  • ENSP00000461737
  • ENST00000573306
  • ENSP00000461084
  • ENST00000615701
  • ENSP00000483670
  • ENST00000617313
  • ENSP00000479716

Symbol
  • C21orf55
  • C21orf78
  • C21orf55
  • C21orf78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
small molecule perturbation
0.74
cell type or tissue
0.65
tissue sample
0.65
cellular component
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.35   (req: < 5)
View Publications
Gene RIFs: 0   (req: <= 3)
Antibodies: 108   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.35   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
Go To Tool
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
Go To Tool
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
Go To Tool
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Go To Tool
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
1 – 10 of 66
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
p_int:  0.999999791
p_ni:  5.7e-8
p_wrong:  1.51e-7
Data Source:  BioPlex
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.999998153
p_ni:  1.29e-7
p_wrong:  0.000001718
Score:  0.795
Data Source:  BioPlex,STRINGDB
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.999877535
p_ni:  0.000122465
Score:  0.525
Data Source:  BioPlex,STRINGDB
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.937124545
p_ni:  0.028625592
p_wrong:  0.034249863
Score:  0.198
Data Source:  BioPlex,STRINGDB
FAM120C
Tbio
Novelty:  0.03333181
Score:  0.731
Data Source:  STRINGDB
MPLKIP
Tbio
Family:  Enzyme
Novelty:  0.01661924
Score:  0.705
Data Source:  STRINGDB
FAM3B
Tbio
Novelty:  0.00844967
Score:  0.703
Data Source:  STRINGDB
DNAJC18
Tdark
Novelty:  1.38573997
Score:  0.675
Data Source:  STRINGDB
DNAJC9
Tbio
Novelty:  0.25748073
Score:  0.668
Data Source:  STRINGDB
DNAJC8
Tbio
Novelty:  0.27669763
Score:  0.666
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Crohn's disease
EFO_0000384
ENSG00000177692
2
1
0
1.1
67.8
Crohn's disease
EFO_0000384
ENSG00000262911
2
1
0
1.1
67.8
psoriasis
EFO_0000676
ENSG00000177692
1
2
0
1.1
39.4
psoriasis
EFO_0000676
ENSG00000262911
1
2
0
1.1
39.4
multiple sclerosis
EFO_0003885
ENSG00000262911
1
1
0
1.1
33.1
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Crohn's disease
EFO_0000384
0
1.1
67.8
Crohn's disease
EFO_0000384
0
1.1
67.8
psoriasis
EFO_0000676
0
1.1
39.4
psoriasis
EFO_0000676
0
1.1
39.4
multiple sclerosis
EFO_0003885
0
1.1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C28
699233
Mouse
DnaJ heat shock protein family (Hsp40) member C28
MGI:2181053
246738
Rat
DnaJ heat shock protein family (Hsp40) member C28
RGD:1359589
360699
Dog
DnaJ heat shock protein family (Hsp40) member C28
100688021
Horse
DnaJ heat shock protein family (Hsp40) member C28
100052371
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C28
Mouse
DnaJ heat shock protein family (Hsp40) member C28
Rat
DnaJ heat shock protein family (Hsp40) member C28
Dog
DnaJ heat shock protein family (Hsp40) member C28
Horse
DnaJ heat shock protein family (Hsp40) member C28
Publication Statistics
PubMed Score 33.35
PubMed score by year
PubTator Score 0.06
PubTator score by year
Related Publications
Items per page:
0 of 0
PMID
Year
Title