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Tbio
SDHAF2
Succinate dehydrogenase assembly factor 2, mitochondrial

Protein Summary
Description
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301761
  • ENSP00000301761
  • ENSG00000167985

Symbol
  • C11orf79
  • PGL2
  • SDH5
  • PGL2
  • SDH5
  • C11orf79
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.87
disease perturbation
0.74
tissue sample
0.64
tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.19   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.19   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (48)
1 – 10 of 48
SDHA
Tbio
Family: Enzyme
Novelty: 0.00223171
p_int: 0.999999954
p_wrong: 4.5e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
SDHB
Tbio
Family: Enzyme
Novelty: 0.0010199
Score: 0.952
Data Source: STRINGDB
SDHD
Tbio
Family: Enzyme
Novelty: 0.00167904
Score: 0.914
Data Source: STRINGDB
TMEM127
Tbio
Novelty: 0.0237211
Score: 0.895
Data Source: STRINGDB
SDHC
Tbio
Family: Enzyme
Novelty: 0.0005776
Score: 0.86
Data Source: STRINGDB
OXCT1
Tbio
Family: Enzyme
Novelty: 0.00283394
Score: 0.821
Data Source: STRINGDB
CTTN
Tbio
Novelty: 0.0017962
Score: 0.813
Data Source: STRINGDB
SDHAF1
Tbio
Family: Enzyme
Novelty: 0.1401114
Score: 0.79
Data Source: STRINGDB
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
Score: 0.78
Data Source: STRINGDB
PGLS
Tbio
Family: Enzyme
Novelty: 0.03252394
Score: 0.73
Data Source: STRINGDB
Publication Statistics
PubMed Score  139.19

PubMed score by year
PubTator Score  90.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer