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Tclin
NDUFB11
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276062
  • ENSP00000276062
  • ENSG00000147123
  • ENST00000377811
  • ENSP00000367042

Symbol
  • ESSS
  • Np15
  • P17.3
  • NP17.3
  • CI-ESSS
  • MC1DN30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
cellular component
0.91
histone modification site profile
0.91
transcription factor perturbation
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.56   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.56   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (162)
NDUFB7
Tclin
Family:  Enzyme
Novelty:  0.14580093
p_int:  0.999999991
p_ni:  6e-9
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB6
Tclin
Family:  Enzyme
Novelty:  0.075245
p_int:  0.999999699
p_ni:  3.01e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS4
Tclin
Family:  Enzyme
Novelty:  0.00787292
p_int:  0.999999537
p_ni:  4.63e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFA12
Tclin
Family:  Enzyme
Novelty:  0.04679316
p_int:  0.999999299
p_ni:  7.01e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFA7
Tclin
Family:  Enzyme
Novelty:  0.16417588
p_int:  0.999998576
p_ni:  0.000001424
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
p_int:  0.999997945
p_ni:  0.000002055
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
p_int:  0.999997769
p_ni:  0.000002231
Score:  0.998
Data Source:  BioPlex,STRINGDB
NDUFB9
Tclin
Family:  Enzyme
Novelty:  0.00715628
p_int:  0.999995335
p_ni:  0.000003323
p_wrong:  0.000001342
Score:  0.998
Data Source:  BioPlex,STRINGDB
MT-ND5
Tclin
Family:  Enzyme
Novelty:  0.00223164
p_int:  0.999992237
p_ni:  0.000007763
p_wrong:  1e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
NDUFB3
Tclin
Family:  Enzyme
Novelty:  0.13020753
p_int:  0.9999813
p_ni:  0.000018693
p_wrong:  7e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Complex I biogenesis (R-HSA-6799198)

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Find Similar Targets
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B11
VGNC:14736
473588
Mouse
MGI:1349919
104130
Rat
RGD:1563698
299310
Dog
NADH:ubiquinone oxidoreductase subunit B11
VGNC:43700
480894
Horse
NADH:ubiquinone oxidoreductase subunit B11
VGNC:20637
100060719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B11
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit B11
Horse
NADH:ubiquinone oxidoreductase subunit B11
Publication Statistics
PubMed Score 24.56
PubMed score by year
PubTator Score 38.88
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title