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Tbio
DDIT4
DNA damage-inducible transcript 4 protein

Protein Summary
Description
Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307365
  • ENSP00000307305
  • ENSG00000168209

Symbol
  • REDD1
  • RTP801
  • Dig2
  • REDD1
  • REDD-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
small molecule perturbation
1
transcription factor binding site profile
1
PubMedID
0.99
protein complex
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.74   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.74   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
9.2
hair color
1
1
0
1.1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
9.2
hair color
0
1.1
2.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA damage inducible transcript 4
VGNC:1621
450520
Mouse
MGI:1921997
74747
Rat
RGD:621731
140942
Dog
DNA damage inducible transcript 4
VGNC:39837
489038
Horse
DNA damage inducible transcript 4
VGNC:17076
100072811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA damage inducible transcript 4
Mouse
Rat
Dog
DNA damage inducible transcript 4
Horse
DNA damage inducible transcript 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NX09-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (61)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Metabolic Genes
Reactome
Transcriptional Regulation by TP53
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Metabolic Genes
Transcriptional Regulation by TP53
Gene Ontology Terms (22)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (90)
1 – 10 of 90
TSC2
Tbio
Novelty: 0.00067416
Score: 0.982
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.968
Data Source: STRINGDB
TSC1
Tbio
Novelty: 0.00406614
Score: 0.957
Data Source: STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
Score: 0.938
Data Source: STRINGDB
YWHAB
Tchem
Novelty: 0.00614093
Score: 0.936
Data Source: STRINGDB
TP63
Tbio
Family: TF
Novelty: 0.00336108
Score: 0.931
Data Source: STRINGDB
SFN
Tbio
Novelty: 0.00340233
Score: 0.909
Data Source: STRINGDB
YWHAQ
Tchem
Novelty: 0.00234496
Score: 0.903
Data Source: STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
Score: 0.901
Data Source: STRINGDB
YWHAG
Tbio
Novelty: 0.00845572
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  254.74

PubMed score by year
PubTator Score  88.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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