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Tbio
TRNAU1AP
tRNA selenocysteine 1-associated protein 1

Protein Summary
Description
Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373830
  • ENSP00000362936
  • ENSG00000180098

Symbol
  • SECP43
  • TRSPAP1
  • SECP43
  • PRO1902
  • TRSPAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
virus perturbation
0.85
transcription factor binding site profile
0.65
tissue
0.64
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
PRPF39
Tbio
Novelty:  0.35760414
p_int:  0.87953816
p_ni:  0.12046184
Score:  0.975
Data Source:  BioPlex,STRINGDB
EEFSEC
Tbio
Novelty:  0.00847753
Score:  0.879
Data Source:  STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
Score:  0.877
Data Source:  STRINGDB
SNRPC
Tbio
Novelty:  0.02049921
Score:  0.874
Data Source:  STRINGDB
PSTK
Tbio
Family:  Kinase
Novelty:  0.0280647
Score:  0.87
Data Source:  STRINGDB
SECISBP2
Tbio
Novelty:  0.00678361
Score:  0.854
Data Source:  STRINGDB
SEPSECS
Tbio
Family:  Enzyme
Novelty:  0.00698701
Score:  0.833
Data Source:  STRINGDB
SNRPD3
Tbio
Novelty:  0.02022419
Score:  0.812
Data Source:  STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
Score:  0.777
Data Source:  STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
Score:  0.777
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
2
50.6
self reported educational attainment
1
1
1
10.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
50.6
self reported educational attainment
1
10.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA selenocysteine 1-associated protein 1
740137
Mouse
MGI:1919037
71787
Rat
RGD:619995
65241
Dog
tRNA selenocysteine 1 associated protein 1
VGNC:53477
478164
Horse
tRNA selenocysteine 1 associated protein 1
VGNC:50789
100070713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA selenocysteine 1-associated protein 1
Mouse
Rat
Dog
tRNA selenocysteine 1 associated protein 1
Horse
tRNA selenocysteine 1 associated protein 1
Publication Statistics
PubMed Score 9.43
PubMed score by year
PubTator Score 2.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title