NLRP2
NACHT, LRR and PYD domains-containing protein 2
Protein Summary
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is ...more
- ENST00000339757
- ENSP00000344074
- ENSG00000022556
- ENST00000391721
- ENSP00000375601
- ENST00000427260
- ENSP00000402474
- ENST00000448584
- ENSP00000409370
- ENST00000537859
- ENSP00000440601
- ENST00000543010
- ENSP00000445135
- ENST00000611410
- ENSP00000479220
- ENSG00000275843
- ENST00000611642
- ENSP00000484150
- ENSG00000275082
- ENST00000611676
- ENSP00000481999
- ENSG00000275399
- ENST00000611679
- ENSP00000484354
- ENSG00000278682
- ENST00000611772
- ENSP00000479109
- ENST00000613062
- ENSP00000483281
- ENSG00000273992
- ENST00000613485
- ENSP00000484351
- ENST00000613825
- ENSP00000483963
- ENSG00000274638
- ENST00000613851
- ENSP00000482628
- ENSG00000278789
- ENST00000615173
- ENSP00000482889
- ENST00000615391
- ENSP00000481851
- ENST00000615521
- ENSP00000479352
- ENST00000616040
- ENSP00000478876
- ENST00000616903
- ENSP00000482355
- ENST00000616919
- ENSP00000481564
- ENST00000618018
- ENSP00000483886
- ENST00000618694
- ENSP00000482465
- ENST00000618731
- ENSP00000478787
- ENST00000618789
- ENSP00000478318
- ENSG00000275796
- ENST00000618943
- ENSP00000482309
- ENST00000619281
- ENSP00000478265
- ENST00000619454
- ENSP00000483528
- ENST00000619664
- ENSP00000478774
- ENST00000619885
- ENSP00000483389
- ENST00000621057
- ENSP00000484382
- ENST00000621200
- ENSP00000479783
- ENST00000621239
- ENSP00000479713
- ENST00000621594
- ENSP00000478450
- ENST00000622042
- ENSP00000482253
- ENST00000622216
- ENSP00000482044
- ENST00000622444
- ENSP00000482065
- ENST00000622600
- ENSP00000482727
- ENST00000622773
- ENSP00000484759
- ENST00000622864
- ENSP00000477726
- NALP2
- NBS1
- PAN1
- PYPAF2
- NBS1
- PAN1
- NALP2
- PYPAF2
- CLR19.9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.81 | ||
tissue sample | 0.63 | ||
PubMedID | 0.62 | ||
protein domain | 0.58 | ||
transcription factor | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 157.95 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 157.95 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0