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Tchem
IRAK4
Interleukin-1 receptor-associated kinase 4

Protein Summary
Description
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431837
  • ENSP00000390327
  • ENSG00000198001
  • ENST00000440781
  • ENSP00000408734
  • ENST00000551736
  • ENSP00000446490
  • ENST00000613694
  • ENSP00000479889

Symbol
  • IPD1
  • REN64
  • IRAK-4
  • NY-REN-64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.87
virus perturbation
0.83
kinase perturbation
0.76
small molecule perturbation
0.69


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.56   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 712   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.56   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 712   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 857
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor associated kinase 4
VGNC:5434
466962
Macaque
interleukin 1 receptor associated kinase 4
700568
Mouse
MGI:2182474
266632
Rat
RGD:1305303
300177
Dog
interleukin 1 receptor associated kinase 4
VGNC:42089
486601
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 receptor associated kinase 4
Macaque
interleukin 1 receptor associated kinase 4
Mouse
Rat
Dog
interleukin 1 receptor associated kinase 4
Protein Structure (37 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NWZ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 37
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (227)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases associated with the TLR signaling cascade
Reactome
Diseases of Immune System
Reactome
IRAK4 deficiency (TLR2/4)
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases associated with the TLR signaling cascade
Diseases of Immune System
IRAK4 deficiency (TLR2/4)
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (121)
1 – 10 of 121
VSIG8
Tdark
Novelty: 1.16023405
p_int: 0.930626002
p_ni: 0.069340109
p_wrong: 0.000033889
Score: 0.202
Data Source: BioPlex,STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.999
Data Source: Reactome,STRINGDB
IL1R1
Tclin
Novelty: 0.0014281
Score: 0.999
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.997
Data Source: Reactome,STRINGDB
IRAK2
Tbio
Family: Kinase
Novelty: 0.01496024
Score: 0.996
Data Source: Reactome,STRINGDB
TIRAP
Tbio
Novelty: 0.00600495
Score: 0.995
Data Source: Reactome,STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.989
Data Source: STRINGDB
IRAK3
Tchem
Family: Kinase
Novelty: 0.01001206
Score: 0.989
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.984
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.982
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  298.56

PubMed score by year
PubTator Score  158.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer