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Tbio
THG1L
Probable tRNA(His) guanylyltransferase

Protein Summary
Description
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231198
  • ENSP00000231198
  • ENSG00000113272

Symbol
  • ICF45
  • ICF45
  • IHG-1
  • hTHG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.91
kinase perturbation
0.71
disease perturbation
0.68
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.59   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.59   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
84.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
84.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA-histidine guanylyltransferase 1 like
VGNC:7158
462226
Mouse
MGI:1913878
66628
Rat
RGD:1359513
303067
Dog
tRNA-histidine guanylyltransferase 1 like
VGNC:47345
479315
Horse
tRNA-histidine guanylyltransferase 1 like
VGNC:24079
100071194
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA-histidine guanylyltransferase 1 like
Mouse
Rat
Dog
tRNA-histidine guanylyltransferase 1 like
Horse
tRNA-histidine guanylyltransferase 1 like
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (12)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (40)
1 – 10 of 40
SH3BP5L
Tdark
Novelty: 1.7921497
p_int: 0.999999387
p_ni: 6.04e-7
p_wrong: 9e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
PACSIN2
Tbio
Family: Enzyme
Novelty: 0.0250489
p_int: 0.999997189
p_ni: 3.2e-7
p_wrong: 0.000002491
Score: 0.534
Data Source: BioPlex,STRINGDB
ZNF524
Tdark
Family: TF
Novelty: 2.44930764
p_int: 0.999994344
p_ni: 0.000005653
p_wrong: 3e-9
Score: 0.29
Data Source: BioPlex,STRINGDB
HARS
Tchem
Family: Enzyme
Novelty: 0.01271582
Score: 0.793
Data Source: STRINGDB
NSUN2
Tbio
Family: Enzyme
Novelty: 0.01546947
Score: 0.694
Data Source: STRINGDB
HARS2
Tbio
Family: Enzyme
Novelty: 0.00230399
Score: 0.682
Data Source: STRINGDB
ADAM19
Tbio
Family: Enzyme
Novelty: 0.01830281
Score: 0.677
Data Source: STRINGDB
ELMOD1
Tbio
Novelty: 0.28255275
Score: 0.644
Data Source: STRINGDB
SOX30
Tbio
Family: TF
Novelty: 0.04791535
Score: 0.613
Data Source: STRINGDB
UBLCP1
Tchem
Family: Enzyme
Novelty: 0.14438023
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.59

PubMed score by year
PubTator Score  6.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer