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Tdark
ASB6
Ankyrin repeat and SOCS box protein 6

Protein Summary
Description
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277458
  • ENSP00000277458
  • ENSG00000148331
  • ENST00000277459
  • ENSP00000277459
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
tissue sample
0.71
disease perturbation
0.68
kinase perturbation
0.66
cell line
0.56


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 6
VGNC:13854
742408
Macaque
ankyrin repeat and SOCS box containing 6
716732
Mouse
MGI:1919573
72323
Rat
RGD:1308445
296627
Dog
ankyrin repeat and SOCS box containing 6
VGNC:38166
491299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 6
Macaque
ankyrin repeat and SOCS box containing 6
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NWX5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (348)
1 – 10 of 348
CUL5
Tbio
Novelty:  0.00792494
p_int:  1
Score:  0.961
Data Source:  BioPlex,STRINGDB
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.999992043
p_ni:  0.000007956
p_wrong:  1e-9
Data Source:  BioPlex
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.999945918
p_ni:  0.000046815
p_wrong:  0.000007267
Score:  0.943
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.999469498
p_ni:  0.000530502
Score:  0.632
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999201602
p_ni:  5.56e-7
p_wrong:  0.000797842
Score:  0.985
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.998960202
p_ni:  0.001039788
p_wrong:  1e-8
Score:  0.55
Data Source:  BioPlex,STRINGDB
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.998589285
p_ni:  0.001396474
p_wrong:  0.000014241
Score:  0.548
Data Source:  BioPlex,STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
p_int:  0.99767494
p_ni:  0.00232506
Score:  0.679
Data Source:  BioPlex,STRINGDB
E2F6
Tbio
Family:  TF
Novelty:  0.00753541
p_int:  0.997505823
p_ni:  0.00240081
p_wrong:  0.000093368
Score:  0.256
Data Source:  BioPlex,STRINGDB
CORO7
Tbio
Novelty:  0.14307384
p_int:  0.997390921
p_ni:  0.002272149
p_wrong:  0.00033693
Data Source:  BioPlex
Publication Statistics
PubMed Score  4.17

PubMed score by year
PubTator Score  1.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer