Tbio NMRK1 Nicotinamide riboside kinase 1

Protein Summary

Description

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine. Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NWW6
• Q5W124
• Q8N430
• NRK 1

Gene Name

• NMRK1

Ensembl ID

• ENST00000361092
• ENSP00000354387
• ENSG00000106733
• ENST00000376808
• ENSP00000366004

Symbol

• C9orf95
• NRK1
• NRK1
• C9orf95
• bA235O14.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
transcription factor perturbation	0.91
virus perturbation	0.9
cell type or tissue	0.87
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Nicotinamide Riboside Kinase 1

Protein / Transferase / Glycosyltransferase / Nicotinamide Riboside Kinase 1

DTO Classes

Protein / Kinase / Unclassified Protein / Nicotinamide Riboside Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.89   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.89   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0